Heyen JR - Search Results

1

Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma.

Panowski SH, Srinivasan S, Tan N, Tacheva-Grigorova SK, Smith B, Mak YSL, Ning H, Villanueva J, Wijewarnasuriya D, Lang S, Melton Z, Ghosh A, Dusseaux M, Galetto R, Heyen JR, Sai T, Van Blarcom T, Chaparro-Riggers J, Sasu BJ. Panowski SH, et al. Among authors: heyen jr. Cancer Res. 2022 Jul 18;82(14):2610-2624. doi: 10.1158/0008-5472.CAN-21-2931. Cancer Res. 2022. PMID: 35294525

2

Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity.

Chen SH, Dominik PK, Stanfield J, Ding S, Yang W, Kurd N, Llewellyn R, Heyen J, Wang C, Melton Z, Van Blarcom T, Lindquist KC, Chaparro-Riggers J, Salek-Ardakani S. Chen SH, et al. J Immunother Cancer. 2021 Oct;9(10):e003464. doi: 10.1136/jitc-2021-003464. J Immunother Cancer. 2021. PMID: 34599020 Free PMC article.

3

CD40 agonist-induced IL-12p40 potentiates hepatotoxicity.

Bonnans C, Thomas G, He W, Jung B, Chen W, Liao M, Heyen J, Buetow B, Pillai S, Matsumoto D, Chaparro-Riggers J, Salek-Ardakani S, Qu Y. Bonnans C, et al. J Immunother Cancer. 2020 May;8(1):e000624. doi: 10.1136/jitc-2020-000624. J Immunother Cancer. 2020. PMID: 32474414 Free PMC article.

4

Characterization, biomarkers, and reversibility of a monoclonal antibody-induced immune complex disease in cynomolgus monkeys (Macaca fascicularis).

Heyen JR, Rojko J, Evans M, Brown TP, Bobrowski WF, Vitsky A, Dalton S, Tripathi N, Bollini SS, Johnson T, Lin JC, Khan N, Han B. Heyen JR, et al. Toxicol Pathol. 2014 Jun;42(4):765-73. doi: 10.1177/0192623314522559. Epub 2014 Mar 10. Toxicol Pathol. 2014. PMID: 24616262

5

Cardiovascular effects in rats following exposure to a receptor tyrosine kinase inhibitor.

Aguirre SA, Heyen JR, Collette W 3rd, Bobrowski W, Blasi ER. Aguirre SA, et al. Among authors: heyen jr. Toxicol Pathol. 2010 Apr;38(3):416-28. doi: 10.1177/0192623310364027. Epub 2010 Mar 15. Toxicol Pathol. 2010. PMID: 20231546

6

Pan-FGFR inhibition leads to blockade of FGF23 signaling, soft tissue mineralization, and cardiovascular dysfunction.

Yanochko GM, Vitsky A, Heyen JR, Hirakawa B, Lam JL, May J, Nichols T, Sace F, Trajkovic D, Blasi E. Yanochko GM, et al. Among authors: heyen jr. Toxicol Sci. 2013 Oct;135(2):451-64. doi: 10.1093/toxsci/kft161. Epub 2013 Jul 20. Toxicol Sci. 2013. PMID: 23872713

7

Validation and utility of the PhysioTel™ Digital M11 telemetry implant for cardiovascular data evaluation in cynomolgus monkeys and Beagle dogs.

Cordes JS, Heyen JR, Volberg ML, Poy N, Kreuser S, Shoieb AM, Steidl-Nichols J. Cordes JS, et al. Among authors: heyen jr. J Pharmacol Toxicol Methods. 2016 May-Jun;79:72-9. doi: 10.1016/j.vascn.2016.01.006. Epub 2016 Feb 1. J Pharmacol Toxicol Methods. 2016. PMID: 26844408

8

Sunitinib, a receptor tyrosine kinase inhibitor, increases blood pressure in rats without associated changes in cardiac structure and function.

Blasi E, Heyen J, Patyna S, Hemkens M, Ramirez D, John-Baptiste A, Steidl-Nichols J, McHarg A. Blasi E, et al. Cardiovasc Ther. 2012 Oct;30(5):287-94. doi: 10.1111/j.1755-5922.2011.00278.x. Epub 2011 May 31. Cardiovasc Ther. 2012. PMID: 21884012 Free article.

9

Time course of AQP-2 and ENaC regulation in the kidney in response to PPAR agonists associated with marked edema in rats.

Tiwari S, Blasi ER, Heyen JR, McHarg AD, Ecelbarger CM. Tiwari S, et al. Among authors: heyen jr. Pharmacol Res. 2008 May;57(5):383-92. doi: 10.1016/j.phrs.2008.03.013. Epub 2008 Apr 7. Pharmacol Res. 2008. PMID: 18468451

10

Antisense inhibition of S6 kinase 1 produces improved glucose tolerance and is well tolerated for 4 weeks of treatment in rats.

Younis HS, Hirakawa B, Scott W, Tran P, Bhat G, Affolter T, Chapman J, Heyen J, Chakravarty K, Alton G. Younis HS, et al. Pharmacology. 2011;87(1-2):11-23. doi: 10.1159/000322526. Epub 2010 Dec 20. Pharmacology. 2011. PMID: 21178385

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