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Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19.
Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles JR, Wu JE, Chen Z, Huang YJ, Belman J, Pattekar A, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman AR, Ittner CAG, Gouma S, Dunbar D, Frank I, Huang AC, Vella LA; UPenn COVID Processing Unit; Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CS, Wherry EJ. Apostolidis SA, et al. Among authors: sarkar a. Front Immunol. 2022 Mar 3;13:834988. doi: 10.3389/fimmu.2022.834988. eCollection 2022. Front Immunol. 2022. PMID: 35309299 Free PMC article.
Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis.
Gollomp K, Sarkar A, Harikumar S, Seeholzer SH, Arepally GM, Hudock K, Rauova L, Kowalska MA, Poncz M. Gollomp K, et al. Among authors: sarkar a. Blood. 2020 Mar 5;135(10):743-754. doi: 10.1182/blood.2019002329. Blood. 2020. PMID: 31722003 Free PMC article.
FcRn augments induction of tissue factor activity by IgG-containing immune complexes.
Cines DB, Zaitsev S, Rauova L, Rux AH, Stepanova V, Krishnaswamy S, Sarkar A, Kowalska MA, Zhao G, Mast AE, Blumberg LJ, McCrae KR, Poncz M, Hubbard JJ, Pyzik M, Blumberg RS. Cines DB, et al. Among authors: sarkar a. Blood. 2020 Jun 4;135(23):2085-2093. doi: 10.1182/blood.2019001133. Blood. 2020. PMID: 32187355 Free PMC article.
Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19.
Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles J, Wu JE, Chen Z, Huang YJ, Pattekar A, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman AR, Ittner CAG, Gouma S, Dunbar D, Frank I, Huang AC, Vella LA; UPenn COVID Processing Unit; Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CS, Wherry EJ. Apostolidis SA, et al. Among authors: sarkar a. bioRxiv [Preprint]. 2021 May 3:2021.05.01.442279. doi: 10.1101/2021.05.01.442279. bioRxiv. 2021. Update in: Front Immunol. 2022 Mar 03;13:834988. doi: 10.3389/fimmu.2022.834988 PMID: 33972943 Free PMC article. Updated. Preprint.
Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes.
Khandelwal S, Barnes A, Rauova L, Sarkar A, Rux AH, Yarovoi SV, Zaitsev SS, Lambris JD, Myoung SS, Johnson A, Lee GM, Duarte M, Poncz M, Arepally GM, Cines DB. Khandelwal S, et al. Among authors: sarkar a. Blood. 2021 Nov 25;138(21):2106-2116. doi: 10.1182/blood.2020009487. Blood. 2021. PMID: 34189574 Free PMC article.
Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury.
Ngo ATP, Sarkar A, Yarovoi I, Levine ND, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K. Ngo ATP, et al. Among authors: sarkar a. bioRxiv [Preprint]. 2023 Jan 9:2023.01.09.522931. doi: 10.1101/2023.01.09.522931. bioRxiv. 2023. Update in: JCI Insight. 2023 Nov 22;8(22):e171054. doi: 10.1172/jci.insight.171054 PMID: 36711969 Free PMC article. Updated. Preprint.
G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics.
Mazharian A, Bertin O, Sarkar A, Augros J, Bornert A, Loubière C, Jönsson F, Warwicker J, Abbott WM, Dushek O, Vayne C, Rauova L, Fütterer K, Rollin J, Poncz M, Senis YA. Mazharian A, et al. Among authors: sarkar a. bioRxiv [Preprint]. 2024 May 14:2024.05.10.593500. doi: 10.1101/2024.05.10.593500. bioRxiv. 2024. PMID: 38798354 Free PMC article. Preprint.
2,631 results