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Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity.
Barreira da Silva R, Leitao RM, Pechuan-Jorge X, Werneke S, Oeh J, Javinal V, Wang Y, Phung W, Everett C, Nonomiya J, Arnott D, Lu C, Hsiao YC, Koerber JT, Hötzel I, Ziai J, Modrusan Z, Pillow TH, Roose-Girma M, Schartner JM, Merchant M, Rutz S, Eidenschenk C, Mellman I, Albert ML. Barreira da Silva R, et al. Among authors: arnott d. Nat Immunol. 2022 Apr;23(4):568-580. doi: 10.1038/s41590-022-01153-x. Epub 2022 Mar 21. Nat Immunol. 2022. PMID: 35314846
Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes.
Arenzana TL, Lianoglou S, Seki A, Eidenschenk C, Cheung T, Seshasayee D, Hagenbeek T, Sambandam A, Noubade R, Peng I, Lesch J, DeVoss J, Wu X, Lee WP, Caplazi P, Webster J, Liu J, Pham VC, Arnott D, Lill JR, Modrusan Z, Dey A, Rutz S. Arenzana TL, et al. Among authors: arnott d. Sci Immunol. 2018 Apr 20;3(22):eaal1953. doi: 10.1126/sciimmunol.aal1953. Sci Immunol. 2018. PMID: 29678836
The ubiquitin ligase COP1 is a critical negative regulator of p53.
Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, O'Rourke K, Koeppen H, Dixit VM. Dornan D, et al. Among authors: arnott d. Nature. 2004 May 6;429(6987):86-92. doi: 10.1038/nature02514. Epub 2004 Apr 21. Nature. 2004. PMID: 15103385
COP1 is a tumour suppressor that causes degradation of ETS transcription factors.
Vitari AC, Leong KG, Newton K, Yee C, O'Rourke K, Liu J, Phu L, Vij R, Ferrando R, Couto SS, Mohan S, Pandita A, Hongo JA, Arnott D, Wertz IE, Gao WQ, French DM, Dixit VM. Vitari AC, et al. Among authors: arnott d. Nature. 2011 May 15;474(7351):403-6. doi: 10.1038/nature10005. Nature. 2011. PMID: 21572435
Phosphorylation of NLRC4 is critical for inflammasome activation.
Qu Y, Misaghi S, Izrael-Tomasevic A, Newton K, Gilmour LL, Lamkanfi M, Louie S, Kayagaki N, Liu J, Kömüves L, Cupp JE, Arnott D, Monack D, Dixit VM. Qu Y, et al. Among authors: arnott d. Nature. 2012 Oct 25;490(7421):539-42. doi: 10.1038/nature11429. Epub 2012 Aug 12. Nature. 2012. PMID: 22885697
A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase.
Morisaki JH, Smith PA, Date SV, Kajihara KK, Truong CL, Modrusan Z, Yan D, Kang J, Xu M, Shah IM, Mintzer R, Kofoed EM, Cheung TK, Arnott D, Koehler MF, Heise CE, Brown EJ, Tan MW, Hazenbos WL. Morisaki JH, et al. Among authors: arnott d. mBio. 2016 Sep 6;7(5):e00412-16. doi: 10.1128/mBio.00412-16. mBio. 2016. PMID: 27601569 Free PMC article.
Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia.
Cuellar TL, Herzner AM, Zhang X, Goyal Y, Watanabe C, Friedman BA, Janakiraman V, Durinck S, Stinson J, Arnott D, Cheung TK, Chaudhuri S, Modrusan Z, Doerr JM, Classon M, Haley B. Cuellar TL, et al. Among authors: arnott d. J Cell Biol. 2017 Nov 6;216(11):3535-3549. doi: 10.1083/jcb.201612160. Epub 2017 Sep 8. J Cell Biol. 2017. PMID: 28887438 Free PMC article.
Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.
Raisner R, Kharbanda S, Jin L, Jeng E, Chan E, Merchant M, Haverty PM, Bainer R, Cheung T, Arnott D, Flynn EM, Romero FA, Magnuson S, Gascoigne KE. Raisner R, et al. Among authors: arnott d. Cell Rep. 2018 Aug 14;24(7):1722-1729. doi: 10.1016/j.celrep.2018.07.041. Cell Rep. 2018. PMID: 30110629 Free article.
176 results