Balskus EP - Search Results

1

The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia.

Reed AD, Fletcher JR, Huang YY, Thanissery R, Rivera AJ, Parsons RJ, Stewart AK, Kountz DJ, Shen A, Balskus EP, Theriot CM. Reed AD, et al. Among authors: balskus ep. mSphere. 2022 Apr 27;7(2):e0092621. doi: 10.1128/msphere.00926-21. Epub 2022 Mar 30. mSphere. 2022. PMID: 35350846 Free PMC article.

2

Elucidation of chalkophomycin biosynthesis reveals N-hydroxypyrrole-forming enzymes.

Crooke AM, Chand AK, Cui Z, Balskus EP. Crooke AM, et al. Among authors: balskus ep. bioRxiv [Preprint]. 2024 Apr 18:2024.01.24.577118. doi: 10.1101/2024.01.24.577118. bioRxiv. 2024. Update in: J Am Chem Soc. 2024 Jun 12;146(23):16268-16280. doi: 10.1021/jacs.4c04712 PMID: 38328124 Free PMC article. Updated. Preprint.

3

Thoughts for the future.

Alkhalaf LM, Arrowsmith C, Balskus EP, Bergamini G, Bhandari R, Chang CJ, Chen P, Chen X, Ciulli A, Cricco JA, Davis BG, Delbianco M, Dudareva N, Dueber E, Ferguson F, de Giuseppe PO, Hamachi I, Hammond MC, Hatzios SK, Do Heo W, Janet JP, Kamat SS, Knapp S, Krishnan Y, Lang K, Laraia L, Leveson-Gower RB, Li XD, Liu DR, Liu MF, London N, Mahanta N, Mayor-Ruiz C, Muir T, Murakami MT, Rhee HW, Robers M, Satz A, Schulman BA, Shen B, Shoichet B, Strauss E, Suzuki T, Tiwary P, Waldmann H, Ward TR, Weeks A, Weerapana E, Winter G. Alkhalaf LM, et al. Among authors: balskus ep. Nat Chem Biol. 2025 Jan;21(1):6-15. doi: 10.1038/s41589-024-01802-2. Nat Chem Biol. 2025. PMID: 39719500 No abstract available.

4

Complete integration of carbene-transfer chemistry into biosynthesis.

Huang J, Quest A, Cruz-Morales P, Deng K, Pereira JH, Van Cura D, Kakumanu R, Baidoo EEK, Dan Q, Chen Y, Petzold CJ, Northen TR, Adams PD, Clark DS, Balskus EP, Hartwig JF, Mukhopadhyay A, Keasling JD. Huang J, et al. Among authors: balskus ep. Nature. 2023 May;617(7960):403-408. doi: 10.1038/s41586-023-06027-2. Epub 2023 May 3. Nature. 2023. PMID: 37138074 Free PMC article.

5

A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline.

Levin BJ, Huang YY, Peck SC, Wei Y, Martínez-Del Campo A, Marks JA, Franzosa EA, Huttenhower C, Balskus EP. Levin BJ, et al. Among authors: balskus ep. Science. 2017 Feb 10;355(6325):eaai8386. doi: 10.1126/science.aai8386. Science. 2017. PMID: 28183913 Free PMC article.

6

Anaerobic 4-hydroxyproline utilization: Discovery of a new glycyl radical enzyme in the human gut microbiome uncovers a widespread microbial metabolic activity.

Huang YY, Martínez-Del Campo A, Balskus EP. Huang YY, et al. Among authors: balskus ep. Gut Microbes. 2018;9(5):437-451. doi: 10.1080/19490976.2018.1435244. Epub 2018 Jun 4. Gut Microbes. 2018. PMID: 29405826 Free PMC article.

7

Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme.

Backman LR, Huang YY, Andorfer MC, Gold B, Raines RT, Balskus EP, Drennan CL. Backman LR, et al. Among authors: balskus ep. Elife. 2020 Mar 17;9:e51420. doi: 10.7554/eLife.51420. Elife. 2020. PMID: 32180548 Free PMC article.

8

Leveraging Microbial Genomes and Genomic Context for Chemical Discovery.

Kountz DJ, Balskus EP. Kountz DJ, et al. Among authors: balskus ep. Acc Chem Res. 2021 Jul 6;54(13):2788-2797. doi: 10.1021/acs.accounts.1c00100. Epub 2021 Jun 4. Acc Chem Res. 2021. PMID: 34087065 Free PMC article.

9

Biosynthesis of the Unusual Carbon Skeleton of Nocuolin A.

Martins TP, Glasser NR, Kountz DJ, Oliveira P, Balskus EP, Leão PN. Martins TP, et al. Among authors: balskus ep. ACS Chem Biol. 2022 Aug 31;17(9):2528-37. doi: 10.1021/acschembio.2c00464. Online ahead of print. ACS Chem Biol. 2022. PMID: 36044983 Free PMC article.

10

A diversified, widespread microbial gene cluster encodes homologs of methyltransferases involved in methanogenesis.

Kountz DJ, Balskus EP. Kountz DJ, et al. Among authors: balskus ep. bioRxiv [Preprint]. 2023 Nov 11:2023.07.31.551370. doi: 10.1101/2023.07.31.551370. bioRxiv. 2023. PMID: 37577662 Free PMC article. Preprint.

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