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Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo.
Saito Y, Yatabe H, Tamura I, Kondo Y, Ishida R, Seki T, Hiraga K, Eguchi A, Takakusagi Y, Saito K, Oshima N, Ishikita H, Yamamoto K, Krishna MC, Sando S. Saito Y, et al. Among authors: yamamoto k. Sci Adv. 2022 Apr;8(13):eabj2667. doi: 10.1126/sciadv.abj2667. Epub 2022 Mar 30. Sci Adv. 2022. PMID: 35353577 Free PMC article.
Real-Time insight into in vivo redox status utilizing hyperpolarized [1-13C] N-acetyl cysteine.
Yamamoto K, Opina A, Sail D, Blackman B, Saito K, Brender JR, Malinowski RM, Seki T, Oshima N, Crooks DR, Kishimoto S, Saida Y, Otowa Y, Choyke PL, Ardenkjær-Larsen JH, Mitchell JB, Linehan WM, Swenson RE, Krishna MC. Yamamoto K, et al. Sci Rep. 2021 Jun 9;11(1):12155. doi: 10.1038/s41598-021-90921-0. Sci Rep. 2021. PMID: 34108512 Free PMC article.
Dynamic Imaging of Glucose and Lactate Metabolism by 13C-MRS without Hyperpolarization.
Brender JR, Kishimoto S, Merkle H, Reed G, Hurd RE, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Seki T, Oshima N, Yamamoto K, Choyke PL, Mitchell J, Krishna MC. Brender JR, et al. Among authors: yamamoto k. Sci Rep. 2019 Mar 4;9(1):3410. doi: 10.1038/s41598-019-38981-1. Sci Rep. 2019. PMID: 30833588 Free PMC article.
Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect.
Scroggins BT, Matsuo M, White AO, Saito K, Munasinghe JP, Sourbier C, Yamamoto K, Diaz V, Takakusagi Y, Ichikawa K, Mitchell JB, Krishna MC, Citrin DE. Scroggins BT, et al. Among authors: yamamoto k. Clin Cancer Res. 2018 Jul 1;24(13):3137-3148. doi: 10.1158/1078-0432.CCR-17-1957. Epub 2018 Mar 29. Clin Cancer Res. 2018. PMID: 29599412 Free PMC article.
Synthesis and evaluation of 13C-labeled 5-5-dimethyl-1-pyrroline-N-oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized 13C-MRI.
Saito K, Sail D, Yamamoto K, Matsumoto S, Blackman B, Kishimoto S, Brender JR, Swenson RE, Mitchell JB, Krishna MC. Saito K, et al. Among authors: yamamoto k. Free Radic Biol Med. 2019 Feb 1;131:18-26. doi: 10.1016/j.freeradbiomed.2018.11.013. Epub 2018 Nov 22. Free Radic Biol Med. 2019. PMID: 30471347 Free PMC article.
Simple Esterification of [1-13C]-Alpha-Ketoglutarate Enhances Membrane Permeability and Allows for Noninvasive Tracing of Glutamate and Glutamine Production.
AbuSalim JE, Yamamoto K, Miura N, Blackman B, Brender JR, Mushti C, Seki T, Camphausen KA, Swenson RE, Krishna MC, Kesarwala AH. AbuSalim JE, et al. Among authors: yamamoto k. ACS Chem Biol. 2021 Nov 19;16(11):2144-2150. doi: 10.1021/acschembio.1c00561. Epub 2021 Sep 23. ACS Chem Biol. 2021. PMID: 34554724 Free PMC article.
Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice.
Kishimoto S, Brender JR, Crooks DR, Matsumoto S, Seki T, Oshima N, Merkle H, Lin P, Reed G, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Yamamoto K, Choyke PL, Mitchell J, Lane AN, Fan TW, Linehan WM, Krishna MC. Kishimoto S, et al. Among authors: yamamoto k. Elife. 2019 Aug 13;8:e46312. doi: 10.7554/eLife.46312. Elife. 2019. PMID: 31408004 Free PMC article.
Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma.
Yamamoto K, Brender JR, Seki T, Kishimoto S, Oshima N, Choudhuri R, Adler SS, Jagoda EM, Saito K, Devasahayam N, Choyke PL, Mitchell JB, Krishna MC. Yamamoto K, et al. Cancer Res. 2020 Jun 1;80(11):2087-2093. doi: 10.1158/0008-5472.CAN-19-0928. Epub 2020 Apr 3. Cancer Res. 2020. PMID: 32245793 Free PMC article.
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