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Page 1
Genetic instability from a single S phase after whole-genome duplication.
Gemble S, Wardenaar R, Keuper K, Srivastava N, Nano M, Macé AS, Tijhuis AE, Bernhard SV, Spierings DCJ, Simon A, Goundiam O, Hochegger H, Piel M, Foijer F, Storchová Z, Basto R. Gemble S, et al. Among authors: wardenaar r. Nature. 2022 Apr;604(7904):146-151. doi: 10.1038/s41586-022-04578-4. Epub 2022 Mar 30. Nature. 2022. PMID: 35355016 Free PMC article.
E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration.
Sladky VC, Knapp K, Soratroi C, Heppke J, Eichin F, Rocamora-Reverte L, Szabo TG, Bongiovanni L, Westendorp B, Moreno E, van Liere EA, Bakker B, Spierings DCJ, Wardenaar R, Pereyra D, Starlinger P, Schultze S, Trauner M, Stojakovic T, Scharnagl H, Fava LL, Foijer F, de Bruin A, Villunger A. Sladky VC, et al. Among authors: wardenaar r. Dev Cell. 2020 Feb 10;52(3):335-349.e7. doi: 10.1016/j.devcel.2019.12.016. Epub 2020 Jan 23. Dev Cell. 2020. PMID: 31983631 Free article.
A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity.
Nelson L, Tighe A, Golder A, Littler S, Bakker B, Moralli D, Murtuza Baker S, Donaldson IJ, Spierings DCJ, Wardenaar R, Neale B, Burghel GJ, Winter-Roach B, Edmondson R, Clamp AR, Jayson GC, Desai S, Green CM, Hayes A, Foijer F, Morgan RD, Taylor SS. Nelson L, et al. Among authors: wardenaar r. Nat Commun. 2020 Feb 13;11(1):822. doi: 10.1038/s41467-020-14551-2. Nat Commun. 2020. PMID: 32054838 Free PMC article.
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition.
Cohen-Sharir Y, McFarland JM, Abdusamad M, Marquis C, Bernhard SV, Kazachkova M, Tang H, Ippolito MR, Laue K, Zerbib J, Malaby HLH, Jones A, Stautmeister LM, Bockaj I, Wardenaar R, Lyons N, Nagaraja A, Bass AJ, Spierings DCJ, Foijer F, Beroukhim R, Santaguida S, Golub TR, Stumpff J, Storchová Z, Ben-David U. Cohen-Sharir Y, et al. Among authors: wardenaar r. Nature. 2021 Feb;590(7846):486-491. doi: 10.1038/s41586-020-03114-6. Epub 2021 Jan 27. Nature. 2021. PMID: 33505028 Free PMC article.
Transient genomic instability drives tumorigenesis through accelerated clonal evolution.
Shoshani O, Bakker B, de Haan L, Tijhuis AE, Wang Y, Kim DH, Maldonado M, Demarest MA, Artates J, Zhengyu O, Mark A, Wardenaar R, Sasik R, Spierings DCJ, Vitre B, Fisch K, Foijer F, Cleveland DW. Shoshani O, et al. Among authors: wardenaar r. Genes Dev. 2021 Aug 1;35(15-16):1093-1108. doi: 10.1101/gad.348319.121. Epub 2021 Jul 15. Genes Dev. 2021. PMID: 34266887 Free PMC article.
TP53 loss initiates chromosomal instability in fallopian tube epithelial cells.
Bronder D, Tighe A, Wangsa D, Zong D, Meyer TJ, Wardenaar R, Minshall P, Hirsch D, Heselmeyer-Haddad K, Nelson L, Spierings D, McGrail JC, Cam M, Nussenzweig A, Foijer F, Ried T, Taylor SS. Bronder D, et al. Among authors: wardenaar r. Dis Model Mech. 2021 Nov 1;14(11):dmm049001. doi: 10.1242/dmm.049001. Epub 2021 Nov 30. Dis Model Mech. 2021. PMID: 34569598 Free PMC article.
Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models.
Coulson-Gilmer C, Morgan RD, Nelson L, Barnes BM, Tighe A, Wardenaar R, Spierings DCJ, Schlecht H, Burghel GJ, Foijer F, Desai S, McGrail JC, Taylor SS. Coulson-Gilmer C, et al. Among authors: wardenaar r. J Exp Clin Cancer Res. 2021 Oct 16;40(1):323. doi: 10.1186/s13046-021-02124-0. J Exp Clin Cancer Res. 2021. PMID: 34656146 Free PMC article.
The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma.
Bočkaj I, Martini TEI, de Camargo Magalhães ES, Bakker PL, Meeuwsen-de Boer TGJ, Armandari I, Meuleman SL, Mondria MT, Stok C, Kok YP, Bakker B, Wardenaar R, Seiler J, Broekhuis MJC, van den Bos H, Spierings DCJ, Ringnalda FCA, Clevers H, Schüller U, van Vugt MATM, Foijer F, Bruggeman SWM. Bočkaj I, et al. Among authors: wardenaar r. PLoS Genet. 2021 Nov 9;17(11):e1009868. doi: 10.1371/journal.pgen.1009868. eCollection 2021 Nov. PLoS Genet. 2021. PMID: 34752469 Free PMC article.
Diesel exhaust particles distort lung epithelial progenitors and their fibroblast niche.
Wu X, Ciminieri C, Bos IST, Woest ME, D'Ambrosi A, Wardenaar R, Spierings DCJ, Königshoff M, Schmidt M, Kistemaker LEM, Gosens R. Wu X, et al. Among authors: wardenaar r. Environ Pollut. 2022 Jul 15;305:119292. doi: 10.1016/j.envpol.2022.119292. Epub 2022 Apr 18. Environ Pollut. 2022. PMID: 35439594 Free PMC article.
46 results