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Editorial: Antifungal Pipeline: Build It Strong; Build It Better!
Perfect JR, Krysan DJ, Del Poeta M, Selmecki AM, Brown JCS, Cowen LE. Perfect JR, et al. Among authors: krysan dj. Front Cell Infect Microbiol. 2022 Mar 16;12:881272. doi: 10.3389/fcimb.2022.881272. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35372097 Free PMC article. No abstract available.
Analogues of the anti-malaria drug mefloquine have broad spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection.
Guin S, Montoya MC, Wang X, Zarnowski R, Andes DR, Meyers MJ, Williams NS, Krysan DJ. Guin S, et al. Among authors: krysan dj. bioRxiv [Preprint]. 2024 Aug 30:2024.08.29.610379. doi: 10.1101/2024.08.29.610379. bioRxiv. 2024. Update in: Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0130124. doi: 10.1128/aac.01301-24 PMID: 39257751 Free PMC article. Updated. Preprint.
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA Jr, Tatu U, Brown LE, Pizarro J, Cowen LE. Whitesell L, et al. Among authors: krysan dj. Nat Commun. 2019 Jan 24;10(1):402. doi: 10.1038/s41467-018-08248-w. Nat Commun. 2019. PMID: 30679438 Free PMC article.
Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, Cowen LE. Caplan T, et al. Among authors: krysan dj. Cell Chem Biol. 2020 Mar 19;27(3):269-282.e5. doi: 10.1016/j.chembiol.2019.12.008. Epub 2020 Jan 7. Cell Chem Biol. 2020. PMID: 31924499 Free PMC article.
123 results