Yao H - Search Results

1

Optimization of NAMPT activators to achieve in vivo neuroprotective efficacy.

Wang L, Liu M, Zu Y, Yao H, Wu C, Zhang R, Ma W, Lu H, Xi S, Liu Y, Hua L, Wang G, Tang Y. Wang L, et al. Among authors: yao h. Eur J Med Chem. 2022 Jun 5;236:114260. doi: 10.1016/j.ejmech.2022.114260. Epub 2022 Mar 16. Eur J Med Chem. 2022. PMID: 35385807

2

A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway.

Xu S, Yao H, Luo S, Zhang YK, Yang DH, Li D, Wang G, Hu M, Qiu Y, Wu X, Yao H, Xie W, Chen ZS, Xu J. Xu S, et al. Among authors: yao h. J Med Chem. 2017 Feb 23;60(4):1449-1468. doi: 10.1021/acs.jmedchem.6b01652. Epub 2017 Feb 13. J Med Chem. 2017. PMID: 28165738

3

Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation.

Xu S, Yao H, Pei L, Hu M, Li D, Qiu Y, Wang G, Wu L, Yao H, Zhu Z, Xu J. Xu S, et al. Among authors: yao h. Eur J Med Chem. 2017 May 26;132:310-321. doi: 10.1016/j.ejmech.2017.03.055. Epub 2017 Mar 25. Eur J Med Chem. 2017. PMID: 28395199 Free article.

4

Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.

Li W, Xu F, Shuai W, Sun H, Yao H, Ma C, Xu S, Yao H, Zhu Z, Yang DH, Chen ZS, Xu J. Li W, et al. Among authors: yao h. J Med Chem. 2019 Jan 24;62(2):993-1013. doi: 10.1021/acs.jmedchem.8b01755. Epub 2018 Dec 24. J Med Chem. 2019. PMID: 30525584

5

Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.

Yao H, Xu F, Wang G, Xie S, Li W, Yao H, Ma C, Zhu Z, Xu J, Xu S. Yao H, et al. Eur J Med Chem. 2019 Apr 1;167:485-498. doi: 10.1016/j.ejmech.2019.02.014. Epub 2019 Feb 12. Eur J Med Chem. 2019. PMID: 30784881

6

Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors.

Shuai W, Li X, Li W, Xu F, Lu L, Yao H, Yang L, Zhu H, Xu S, Zhu Z, Xu J. Shuai W, et al. Among authors: yao h. Eur J Med Chem. 2020 Jul 1;197:112308. doi: 10.1016/j.ejmech.2020.112308. Epub 2020 Apr 19. Eur J Med Chem. 2020. PMID: 32339853

7

Identification of a Potent Oridonin Analogue for Treatment of Triple-Negative Breast Cancer.

Yao H, Xie S, Ma X, Liu J, Wu H, Lin A, Yao H, Li D, Xu S, Yang DH, Chen ZS, Xu J. Yao H, et al. J Med Chem. 2020 Aug 13;63(15):8157-8178. doi: 10.1021/acs.jmedchem.0c00408. Epub 2020 Jul 21. J Med Chem. 2020. PMID: 32610904

8

Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities.

Zhu H, Li W, Shuai W, Liu Y, Yang L, Tan Y, Zheng T, Yao H, Xu J, Zhu Z, Yang DH, Chen ZS, Xu S. Zhu H, et al. Among authors: yao h. Eur J Med Chem. 2021 Apr 15;216:113316. doi: 10.1016/j.ejmech.2021.113316. Epub 2021 Feb 24. Eur J Med Chem. 2021. PMID: 33676300

9

Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.

Yao H, Uras G, Zhang P, Xu S, Yin Y, Liu J, Qin S, Li X, Allen S, Bai R, Gong Q, Zhang H, Zhu Z, Xu J. Yao H, et al. J Med Chem. 2021 Jun 10;64(11):7483-7506. doi: 10.1021/acs.jmedchem.1c00160. Epub 2021 May 23. J Med Chem. 2021. PMID: 34024109

10

H₂dpa derivatives containing pentadentate ligands: An acyclic adjuvant potentiates meropenem activity in vitro and in vivo against metallo-β-lactamase-producing Enterobacterales.

Chen F, Bai M, Liu W, Kong H, Zhang T, Yao H, Zhang E, Du J, Qin S. Chen F, et al. Among authors: yao h. Eur J Med Chem. 2021 Nov 15;224:113702. doi: 10.1016/j.ejmech.2021.113702. Epub 2021 Jul 13. Eur J Med Chem. 2021. PMID: 34303873

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