Wüthrich K - Search Results

1

Dual-acting antitumor agents targeting the A_2A adenosine receptor and histone deacetylases: Design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives.

Zhang J, Luo Z, Duan W, Yang K, Ling L, Yan W, Liu R, Wüthrich K, Jiang H, Xie C, Cheng J. Zhang J, et al. Among authors: wuthrich k. Eur J Med Chem. 2022 Jun 5;236:114326. doi: 10.1016/j.ejmech.2022.114326. Epub 2022 Mar 29. Eur J Med Chem. 2022. PMID: 35390714

2

A_2A adenosine receptor functional states characterized by ¹⁹F-NMR.

Sušac L, Eddy MT, Didenko T, Stevens RC, Wüthrich K. Sušac L, et al. Among authors: wuthrich k. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12733-12738. doi: 10.1073/pnas.1813649115. Epub 2018 Nov 21. Proc Natl Acad Sci U S A. 2018. PMID: 30463958 Free PMC article.

3

Tumor Immunotherapy Using A_2A Adenosine Receptor Antagonists.

Zhang J, Yan W, Duan W, Wüthrich K, Cheng J. Zhang J, et al. Among authors: wuthrich k. Pharmaceuticals (Basel). 2020 Sep 8;13(9):237. doi: 10.3390/ph13090237. Pharmaceuticals (Basel). 2020. PMID: 32911819 Free PMC article. Review.

4

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A_2A Adenosine Receptor.

Eddy MT, Lee MY, Gao ZG, White KL, Didenko T, Horst R, Audet M, Stanczak P, McClary KM, Han GW, Jacobson KA, Stevens RC, Wüthrich K. Eddy MT, et al. Among authors: wuthrich k. Cell. 2018 Jan 11;172(1-2):68-80.e12. doi: 10.1016/j.cell.2017.12.004. Epub 2017 Dec 28. Cell. 2018. PMID: 29290469 Free PMC article.

5

Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A_2A Adenosine Receptor.

Eddy MT, Gao ZG, Mannes P, Patel N, Jacobson KA, Katritch V, Stevens RC, Wüthrich K. Eddy MT, et al. Among authors: wuthrich k. J Am Chem Soc. 2018 Jul 5;140(26):8228-8235. doi: 10.1021/jacs.8b03805. Epub 2018 Jun 20. J Am Chem Soc. 2018. PMID: 29874058 Free PMC article.

6

A_2A Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch.

Eddy MT, Martin BT, Wüthrich K. Eddy MT, et al. Among authors: wuthrich k. Structure. 2021 Feb 4;29(2):170-176.e3. doi: 10.1016/j.str.2020.11.005. Epub 2020 Nov 24. Structure. 2021. PMID: 33238145 Free PMC article.

7

Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins.

Xue D, Xu T, Wang H, Wu M, Yuan Y, Wang W, Tan Q, Zhao F, Zhou F, Hu T, Jiang Z, Liu ZJ, Zhao S, Liu D, Wüthrich K, Tao H. Xue D, et al. Among authors: wuthrich k. Chemistry. 2019 Sep 6;25(50):11635-11640. doi: 10.1002/chem.201903190. Epub 2019 Aug 13. Chemistry. 2019. PMID: 31368214

8

GPCR large-amplitude dynamics by ¹⁹F-NMR of aprepitant bound to the neurokinin 1 receptor.

Pan B, Liu D, Yang L, Wüthrich K. Pan B, et al. Among authors: wuthrich k. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2122682119. doi: 10.1073/pnas.2122682119. Epub 2022 Apr 4. Proc Natl Acad Sci U S A. 2022. PMID: 35377814 Free PMC article.

9

Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy.

Orcajo-Rincón ÁL, Ortega-Gutiérrez S, Serrano P, Torrecillas IR, Wüthrich K, Campillo M, Pardo L, Viso A, Benhamú B, López-Rodríguez ML. Orcajo-Rincón ÁL, et al. Among authors: wuthrich k. J Med Chem. 2011 Feb 24;54(4):1096-100. doi: 10.1021/jm101478n. Epub 2011 Jan 27. J Med Chem. 2011. PMID: 21271718

10

In-Membrane Chemical Modification (IMCM) for Site-Specific Chromophore Labeling of GPCRs.

Sušac L, O'Connor C, Stevens RC, Wüthrich K. Sušac L, et al. Among authors: wuthrich k. Angew Chem Int Ed Engl. 2015 Dec 7;54(50):15246-9. doi: 10.1002/anie.201508506. Epub 2015 Nov 6. Angew Chem Int Ed Engl. 2015. PMID: 26545333 Free PMC article.

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