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A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.
Zhao W, Chen L, Li HM, Wang DJ, Li DS, Chen T, Yuan ZP, Tang YJ. Zhao W, et al. Bioorg Med Chem. 2014 Jun 1;22(11):2998-3007. doi: 10.1016/j.bmc.2014.03.048. Epub 2014 Apr 13. Bioorg Med Chem. 2014. PMID: 24775914
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