Wang J - Search Results

1

Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance.

Wang Z, Wang J, Wang Y, Xiang S, Song X, Tu Z, Zhou Y, Zhang ZM, Zhang Z, Ding K, Lu X. Wang Z, et al. Among authors: wang j, wang y. J Med Chem. 2022 Apr 28;65(8):6325-6337. doi: 10.1021/acs.jmedchem.2c00308. Epub 2022 Apr 15. J Med Chem. 2022. PMID: 35426680

2

Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer.

Cao Z, Yang F, Wang J, Gu Z, Lin S, Wang P, An J, Liu T, Li Y, Li Y, Lin H, Zhao Y, He B. Cao Z, et al. Among authors: wang j, wang p. J Med Chem. 2021 Oct 28;64(20):15280-15296. doi: 10.1021/acs.jmedchem.1c01311. Epub 2021 Oct 8. J Med Chem. 2021. PMID: 34624191

3

Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies.

Guo J, Xiang S, Wang J, Zhou Y, Wang Z, Zhang Z, Ding K, Lu X. Guo J, et al. Among authors: wang j, wang z. Eur J Med Chem. 2022 Jan 15;228:114022. doi: 10.1016/j.ejmech.2021.114022. Epub 2021 Nov 30. Eur J Med Chem. 2022. PMID: 34871843

4

Identification of U937^JAK3-M511I Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor.

Si H, Wang J, He R, Yu X, Li S, Huang J, Li J, Tang X, Song X, Tu Z, Zhang Z, Ding K. Si H, et al. Among authors: wang j. Front Oncol. 2022 Jan 17;11:807200. doi: 10.3389/fonc.2021.807200. eCollection 2021. Front Oncol. 2022. PMID: 35111683 Free PMC article.

5

Discovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant.

Li S, Si H, Song X, Lei C, He X, Wang J, Liu Y, Zhou Y, Song JG, Peng L, Tang X, Chan S, Ren X, Tu Z, Li Z, Wang Z, Zhang Z, Ding K. Li S, et al. Among authors: wang j, wang z. J Med Chem. 2022 Aug 11;65(15):10674-10690. doi: 10.1021/acs.jmedchem.2c00922. Epub 2022 Jul 20. J Med Chem. 2022. PMID: 35860875

6

JND4135, a New Type II TRK Inhibitor, Overcomes TRK xDFG and Other Mutation Resistance In Vitro and In Vivo.

Wang J, Zhou Y, Tang X, Yu X, Wang Y, Chan S, Song X, Tu Z, Zhang Z, Lu X, Zhang Z, Ding K. Wang J, et al. Among authors: wang y. Molecules. 2022 Oct 1;27(19):6500. doi: 10.3390/molecules27196500. Molecules. 2022. PMID: 36235036 Free PMC article.

7

Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors.

Chan S, Zhang Y, Wang J, Yu Q, Peng X, Zou J, Zhou L, Tan L, Duan Y, Zhou Y, Hur H, Ai J, Wang Z, Ren X, Zhang Z, Ding K. Chan S, et al. Among authors: wang j, wang z. J Med Chem. 2022 Nov 24;65(22):15374-15390. doi: 10.1021/acs.jmedchem.2c01346. Epub 2022 Nov 10. J Med Chem. 2022. PMID: 36358010

8

Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.

Zhou P, Liang Y, Zhang H, Jiang H, Feng K, Xu P, Wang J, Wang X, Ding K, Luo C, Liu M, Wang Y. Zhou P, et al. Among authors: wang x, wang j, wang y. Eur J Med Chem. 2018 Jan 20;144:817-842. doi: 10.1016/j.ejmech.2017.12.004. Epub 2017 Dec 7. Eur J Med Chem. 2018. PMID: 29306206

9

Zinc-dependent Deacetylase (HDAC) Inhibitors with Different Zinc Binding Groups.

Li Y, Wang F, Chen X, Wang J, Zhao Y, Li Y, He B. Li Y, et al. Among authors: wang f, wang j. Curr Top Med Chem. 2019;19(3):223-241. doi: 10.2174/1568026619666190122144949. Curr Top Med Chem. 2019. PMID: 30674261 Review.

10

Cysteine derivatives as acetyl lysine mimics to inhibit zinc-dependent histone deacetylases for treating cancer.

Wang J, Cao Z, Wang F, Wang P, An J, Fu X, Liu T, Li Y, Li Y, Zhao Y, Lin H, He B. Wang J, et al. Among authors: wang f, wang p. Eur J Med Chem. 2021 Dec 5;225:113799. doi: 10.1016/j.ejmech.2021.113799. Epub 2021 Aug 27. Eur J Med Chem. 2021. PMID: 34500130

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