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Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children.
Chatila TA, Benamar M, Chen Q, Chou J, Julé A, Boudra R, Contini P, Crestani E, Wang M, Fong J, Lai P, Rockwitz S, Lee P, Chan TMF, Altun EZ, Kepenekli E, Karakoc-Aydiner E, Ozen A, Boran P, Aygun F, Onal P, Sakalli AAK, Cokugras H, Gelmez M, Öktelik F, Cetin EA, Zhong Y, Taylor M, Irby K, Halasa N, Signa S, Prigione I, Gattorno M, Cotugno N, Amodio D, Geha R, Son MB, Newburger J, Agrawal P, Volpi S, Palma P, Kiykim A, Randolph A, Deniz G, Baris S, De Palma R, Schmitz-Abe K, Charbonnier LM, Henderson L. Chatila TA, et al. Among authors: lai p. Res Sq [Preprint]. 2022 Apr 11:rs.3.rs-1054453. doi: 10.21203/rs.3.rs-1054453/v1. Res Sq. 2022. PMID: 35441180 Free PMC article. Preprint.
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.
Harb H, Benamar M, Lai PS, Contini P, Griffith JW, Crestani E, Schmitz-Abe K, Chen Q, Fong J, Marri L, Filaci G, Del Zotto G, Pishesha N, Kolifrath S, Broggi A, Ghosh S, Gelmez MY, Oktelik FB, Cetin EA, Kiykim A, Kose M, Wang Z, Cui Y, Yu XG, Li JZ, Berra L, Stephen-Victor E, Charbonnier LM, Zanoni I, Ploegh H, Deniz G, De Palma R, Chatila TA. Harb H, et al. Among authors: lai ps. Immunity. 2021 Jun 8;54(6):1186-1199.e7. doi: 10.1016/j.immuni.2021.04.002. Epub 2021 Apr 28. Immunity. 2021. PMID: 33915108 Free PMC article.
Metagenomic assessment of gut microbial communities and risk of severe COVID-19.
Lai P, Nguyen L, Okin D, Drew D, Battista V, Jesudasen S, Kuntz T, Bhosle A, Thompson K, Reinicke T, Lo CH, Woo J, Caraballo A, Berra L, Vieira J, Huang CY, Adhikari UD, Kim M, Sui HY, Magicheva-Gupta M, McIver L, Goldberg M, Kwon D, Huttenhower C, Chan A. Lai P, et al. Res Sq [Preprint]. 2022 Jun 7:rs.3.rs-1717624. doi: 10.21203/rs.3.rs-1717624/v1. Res Sq. 2022. Update in: Genome Med. 2023 Jul 12;15(1):49. doi: 10.1186/s13073-023-01202-6 PMID: 35677075 Free PMC article. Updated. Preprint.
The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children.
Benamar M, Chen Q, Chou J, Julé AM, Boudra R, Contini P, Crestani E, Lai PS, Wang M, Fong J, Rockwitz S, Lee P, Chan TMF, Altun EZ, Kepenekli E, Karakoc-Aydiner E, Ozen A, Boran P, Aygun F, Onal P, Sakalli AAK, Cokugras H, Gelmez MY, Oktelik FB, Cetin EA, Zhong Y, Taylor ML, Irby K, Halasa NB, Mack EH; Overcoming COVID-19 Investigators; Signa S, Prigione I, Gattorno M, Cotugno N, Amodio D, Geha RS, Son MB, Newburger J, Agrawal PB, Volpi S, Palma P, Kiykim A, Randolph AG, Deniz G, Baris S, De Palma R, Schmitz-Abe K, Charbonnier LM, Henderson LA, Chatila TA. Benamar M, et al. Among authors: lai ps. J Clin Invest. 2023 Jan 3;133(1):e163235. doi: 10.1172/JCI163235. J Clin Invest. 2023. PMID: 36282598 Free PMC article.
The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice.
Yang B, Wilkie H, Das M, Timilshina M, Bainter W, Woods B, Daya M, Boorgula MP, Mathias RA, Lai P, Petty CR, Weller E, Harb H, Chatila TA, Leung DYM, Beck LA, Simpson EL, Hata TR, Barnes KC, Phipatanakul W, Leyva-Castillo JM, Geha RS. Yang B, et al. Among authors: lai p. J Allergy Clin Immunol. 2023 May;151(5):1296-1306.e7. doi: 10.1016/j.jaci.2023.01.011. Epub 2023 Jan 21. J Allergy Clin Immunol. 2023. PMID: 36690254 Free PMC article.
Notch4 regulatory T cells and SARS-CoV-2 viremia shape COVID19 survival outcome.
Benamar M, Lai PS, Huang CY, Chen Q, Oktelik FB, Contini P, Wang M, Okin D, Crestani E, Fong J, Fion TMC, Gokbak MN, Harb H, Phipatanakul W, Marri L, Vassallo C, Guastalla A, Kim M, Sui HY, Berra L, Goldberg MB, Angelini C, De Palma R, Chatila TA. Benamar M, et al. Among authors: lai ps. Allergy. 2024 Oct 3. doi: 10.1111/all.16333. Online ahead of print. Allergy. 2024. PMID: 39361431
Prognostic Insights from Longitudinal Multicompartment Study of Host-Microbiota Interactions in Critically Ill Patients.
Kitsios GD, Sayed K, Fitch A, Yang H, Britton N, Shah F, Bain W, Evankovich JW, Qin S, Wang X, Li K, Patel A, Zhang Y, Radder J, Cruz CD, Okin DA, Huang CY, van Tyne D, Benos PV, Methé B, Lai P, Morris A, McVerry BJ. Kitsios GD, et al. Among authors: lai p. Res Sq [Preprint]. 2023 Sep 26:rs.3.rs-3338762. doi: 10.21203/rs.3.rs-3338762/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Jun 3;15(1):4708. doi: 10.1038/s41467-024-48819-8 PMID: 37841841 Free PMC article. Updated. Preprint.
Host DNA depletion on frozen human respiratory samples enables successful metagenomic sequencing for microbiome studies.
Kim M, Parrish RC 2nd, Shah VS, Ross M, Cormier J, Baig A, Huang CY, Brenner L, Neuringer I, Whiteson K, Harris JK, Willis AD, Lai PS. Kim M, et al. Res Sq [Preprint]. 2024 Jan 23:rs.3.rs-3638876. doi: 10.21203/rs.3.rs-3638876/v1. Res Sq. 2024. Update in: Commun Biol. 2024 Nov 28;7(1):1590. doi: 10.1038/s42003-024-07290-3 PMID: 38343829 Free PMC article. Updated. Preprint.
2,935 results