Burk O - Search Results

1

Development and Experimental Validation of Regularized Machine Learning Models Detecting New, Structurally Distinct Activators of PXR.

Hirte S, Burk O, Tahir A, Schwab M, Windshügel B, Kirchmair J. Hirte S, et al. Among authors: burk o. Cells. 2022 Apr 7;11(8):1253. doi: 10.3390/cells11081253. Cells. 2022. PMID: 35455933 Free PMC article.

2

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library.

Mustonen EK, Pantsar T, Rashidian A, Reiner J, Schwab M, Laufer S, Burk O. Mustonen EK, et al. Among authors: burk o. Cells. 2022 Apr 12;11(8):1299. doi: 10.3390/cells11081299. Cells. 2022. PMID: 35455978 Free PMC article.

3

Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor.

Mathäs M, Nusshag C, Burk O, Gödtel-Armbrust U, Herlyn H, Wojnowski L, Windshügel B. Mathäs M, et al. Among authors: burk o. PLoS One. 2014 May 5;9(5):e96263. doi: 10.1371/journal.pone.0096263. eCollection 2014. PLoS One. 2014. PMID: 24797902 Free PMC article.

4

Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.

Kandel BA, Thomas M, Winter S, Damm G, Seehofer D, Burk O, Schwab M, Zanger UM. Kandel BA, et al. Among authors: burk o. Biochim Biophys Acta. 2016 Sep;1859(9):1218-1227. doi: 10.1016/j.bbagrm.2016.03.007. Epub 2016 Mar 17. Biochim Biophys Acta. 2016. PMID: 26994748

5

Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.

Jeske J, Windshügel B, Thasler WE, Schwab M, Burk O. Jeske J, et al. Among authors: burk o. Arch Toxicol. 2017 Jun;91(6):2375-2390. doi: 10.1007/s00204-017-1948-3. Epub 2017 Mar 13. Arch Toxicol. 2017. PMID: 28289823

6

Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.

Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O. Jeske J, et al. Among authors: burk o. Biochem Pharmacol. 2017 Jul 15;136:122-135. doi: 10.1016/j.bcp.2017.04.013. Epub 2017 Apr 13. Biochem Pharmacol. 2017. PMID: 28414139

7

Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B. Burk O, et al. Arch Toxicol. 2018 Apr;92(4):1435-1451. doi: 10.1007/s00204-018-2165-4. Epub 2018 Jan 22. Arch Toxicol. 2018. PMID: 29356861

8

Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor.

Burk O, Kronenberger T, Keminer O, Lee SML, Schiergens TS, Schwab M, Windshügel B. Burk O, et al. Mol Pharmacol. 2021 Mar;99(3):184-196. doi: 10.1124/molpharm.120.000116. Epub 2021 Jan 22. Mol Pharmacol. 2021. PMID: 33483427

9

PXR variants and artemisinin use in Vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin.

Piedade R, Schaeffeler E, Winter S, Asimus S, Schwab M, Ashton M, Burk O, Gil JP. Piedade R, et al. Among authors: burk o. Antimicrob Agents Chemother. 2012 Apr;56(4):2153-7. doi: 10.1128/AAC.06009-11. Epub 2012 Jan 17. Antimicrob Agents Chemother. 2012. PMID: 22252826 Free PMC article.

10

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.

Bitter A, Rümmele P, Klein K, Kandel BA, Rieger JK, Nüssler AK, Zanger UM, Trauner M, Schwab M, Burk O. Bitter A, et al. Among authors: burk o. Arch Toxicol. 2015 Nov;89(11):2089-103. doi: 10.1007/s00204-014-1348-x. Epub 2014 Sep 3. Arch Toxicol. 2015. PMID: 25182422

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