Yao W - Search Results

1

Mcl-1 levels critically impact the sensitivities of human colorectal cancer cells to APG-1252-M1, a novel Bcl-2/Bcl-X_L dual inhibitor that induces Bax-dependent apoptosis.

Yao W, Bai L, Wang S, Zhai Y, Sun SY. Yao W, et al. Neoplasia. 2022 Jul;29:100798. doi: 10.1016/j.neo.2022.100798. Epub 2022 Apr 21. Neoplasia. 2022. PMID: 35462114 Free PMC article.

2

BRD4 Levels Determine the Response of Human Lung Cancer Cells to BET Degraders That Potently Induce Apoptosis through Suppression of Mcl-1.

Zong D, Gu J, Cavalcante GC, Yao W, Zhang G, Wang S, Owonikoko TK, He X, Sun SY. Zong D, et al. Among authors: yao w. Cancer Res. 2020 Jun 1;80(11):2380-2393. doi: 10.1158/0008-5472.CAN-19-3674. Epub 2020 Mar 10. Cancer Res. 2020. PMID: 32156781

3

Therapeutic potential of the novel Bcl-2/Bcl-X_L dual inhibitor, APG1252, alone or in combination against non-small cell lung cancer.

Qian L, Vallega KA, Yao W, Wang D, Zhai Y, He X, Sun SY. Qian L, et al. Among authors: yao w. Mol Carcinog. 2022 Nov;61(11):1031-1042. doi: 10.1002/mc.23458. Epub 2022 Sep 6. Mol Carcinog. 2022. PMID: 36066010

4

Enhancing therapeutic efficacy of the MEK inhibitor, MEK162, by blocking autophagy or inhibiting PI3K/Akt signaling in human lung cancer cells.

Yao W, Yue P, Zhang G, Owonikoko TK, Khuri FR, Sun SY. Yao W, et al. Cancer Lett. 2015 Aug 1;364(1):70-8. doi: 10.1016/j.canlet.2015.04.028. Epub 2015 Apr 29. Cancer Lett. 2015. PMID: 25937299 Free PMC article.

5

The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5.

Han B, Yao W, Oh YT, Tong JS, Li S, Deng J, Yue P, Khuri FR, Sun SY. Han B, et al. Among authors: yao w. Oncotarget. 2015 Jul 10;6(19):17532-42. doi: 10.18632/oncotarget.3947. Oncotarget. 2015. PMID: 26009898 Free PMC article.

6

The BET bromodomain inhibitor, JQ1, facilitates c-FLIP degradation and enhances TRAIL-induced apoptosis independent of BRD4 and c-Myc inhibition.

Yao W, Yue P, Khuri FR, Sun SY. Yao W, et al. Oncotarget. 2015 Oct 27;6(33):34669-79. doi: 10.18632/oncotarget.5785. Oncotarget. 2015. PMID: 26415225 Free PMC article.

7

Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.

Shi P, Oh YT, Zhang G, Yao W, Yue P, Li Y, Kanteti R, Riehm J, Salgia R, Owonikoko TK, Ramalingam SS, Chen M, Sun SY. Shi P, et al. Among authors: yao w. Cancer Lett. 2016 Oct 1;380(2):494-504. doi: 10.1016/j.canlet.2016.07.021. Epub 2016 Jul 19. Cancer Lett. 2016. PMID: 27450722

8

Expression of Death Receptor 4 Is Positively Regulated by MEK/ERK/AP-1 Signaling and Suppressed upon MEK Inhibition.

Yao W, Oh YT, Deng J, Yue P, Deng L, Huang H, Zhou W, Sun SY. Yao W, et al. J Biol Chem. 2016 Oct 7;291(41):21694-21702. doi: 10.1074/jbc.M116.738302. Epub 2016 Aug 30. J Biol Chem. 2016. PMID: 27576686 Free PMC article.

9

Co-inhibition of BET and proteasome enhances ER stress and Bim-dependent apoptosis with augmented cancer therapeutic efficacy.

Qian G, Yao W, Zhang S, Bajpai R, Hall WD, Shanmugam M, Lonial S, Sun SY. Qian G, et al. Among authors: yao w. Cancer Lett. 2018 Oct 28;435:44-54. doi: 10.1016/j.canlet.2018.07.033. Epub 2018 Jul 29. Cancer Lett. 2018. PMID: 30059709

10

MEK or ERK inhibition effectively abrogates emergence of acquired osimertinib resistance in the treatment of epidermal growth factor receptor-mutant lung cancers.

Gu J, Yao W, Shi P, Zhang G, Owonikoko TK, Ramalingam SS, Sun SY. Gu J, et al. Among authors: yao w. Cancer. 2020 Aug 15;126(16):3788-3799. doi: 10.1002/cncr.32996. Epub 2020 Jun 4. Cancer. 2020. PMID: 32497272 Free PMC article.

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