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β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.
Madhavan SS, Roa Diaz S, Peralta S, Nomura M, King CD, Ceyhan KE, Lin A, Bhaumik D, Foulger AC, Shah S, Blade T, Gray W, Chamoli M, Eap B, Panda O, Diaz D, Garcia TY, Stubbs BJ, Ulrich SM, Lithgow GJ, Schilling B, Verdin E, Chaudhuri AR, Newman JC. Madhavan SS, et al. Among authors: roa diaz s. Cell Chem Biol. 2024 Nov 25:S2451-9456(24)00459-8. doi: 10.1016/j.chembiol.2024.11.001. Online ahead of print. Cell Chem Biol. 2024. PMID: 39626664 Free article.
Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults in a randomized, parallel arm, double-blind, placebo-controlled, pilot study.
Stubbs BJ, Stephens EB, Senadheera C, Peralta S, Roa-Diaz S, Alexander L, Silverman-Martin W, Garcia TY, Yukawa M, Morris J, Blonquist TM, Johnson JB, Newman JC. Stubbs BJ, et al. Among authors: roa diaz s. J Nutr Health Aging. 2024 Sep;28(9):100329. doi: 10.1016/j.jnha.2024.100329. Epub 2024 Aug 12. J Nutr Health Aging. 2024. PMID: 39137624 Free article. Clinical Trial.
Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults, a randomized, parallel arm, double-blind, placebo-controlled, pilot study.
Stubbs BJ, Stephens EB, Senadheera C, Peralta S, Roa-Diaz S, Alexander L, Silverman-Martin W, Garcia TY, Yukawa M, Morris J, Blonquist TM, Johnson JB, Newman JC. Stubbs BJ, et al. Among authors: roa diaz s. medRxiv [Preprint]. 2024 May 5:2024.05.03.24306699. doi: 10.1101/2024.05.03.24306699. medRxiv. 2024. Update in: J Nutr Health Aging. 2024 Sep;28(9):100329. doi: 10.1016/j.jnha.2024.100329 PMID: 38746215 Free PMC article. Updated. Preprint.
A randomized open-label, observational study of the novel ketone ester, bis octanoyl (R)-1,3-butanediol, and its acute effect on ß-hydroxybutyrate and glucose concentrations in healthy older adults.
Stephens EB, Senadheera C, Roa-Diaz S, Peralta S, Alexander L, Silverman-Martin W, Yukawa M, Morris J, Johnson JB, Newman JC, Stubbs BJ. Stephens EB, et al. Among authors: roa diaz s. medRxiv [Preprint]. 2024 Apr 18:2024.04.16.24305925. doi: 10.1101/2024.04.16.24305925. medRxiv. 2024. PMID: 38699344 Free PMC article. Preprint.
Rationale and protocol for a safety, tolerability and feasibility randomized, parallel group, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms.
Stubbs BJ, Alvarez-Azanedo G, Peralta S, Roa-Diaz S, Gray W, Alexander L, Silverman-Martin W, Garcia T, Blonquist TM, Upadhyay V, Turnbaugh PJ, Johnson JB, Newman JC. Stubbs BJ, et al. Among authors: roa diaz s. medRxiv [Preprint]. 2023 Oct 26:2023.10.25.23297571. doi: 10.1101/2023.10.25.23297571. medRxiv. 2023. Update in: PLoS One. 2024 Sep 18;19(9):e0307951. doi: 10.1371/journal.pone.0307951 PMID: 37961234 Free PMC article. Updated. Preprint.
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.
Madhavan SS, Roa Diaz S, Peralta S, Nomura M, King CD, Lin A, Bhaumik D, Shah S, Blade T, Gray W, Chamoli M, Eap B, Panda O, Diaz D, Garcia TY, Stubbs BJ, Lithgow GJ, Schilling B, Verdin E, Chaudhuri AR, Newman JC. Madhavan SS, et al. Among authors: roa diaz s. bioRxiv [Preprint]. 2023 Jul 3:2023.07.03.547547. doi: 10.1101/2023.07.03.547547. bioRxiv. 2023. Update in: Cell Chem Biol. 2024 Nov 25:S2451-9456(24)00459-8. doi: 10.1016/j.chembiol.2024.11.001 PMID: 37461525 Free PMC article. Updated. Preprint.
Bis Hexanoyl (R)-1,3-Butanediol, a Novel Ketogenic Ester, Acutely Increases Circulating r- and s-ß-Hydroxybutyrate Concentrations in Healthy Adults.
Crabtree CD, Blade T, Hyde PN, Buga A, Kackley ML, Sapper TN, Panda O, Roa-Diaz S, Anthony JC, Newman JC, Volek JS, Stubbs BJ. Crabtree CD, et al. Among authors: roa diaz s. J Am Nutr Assoc. 2023 Feb;42(2):169-177. doi: 10.1080/07315724.2021.2015476. Epub 2022 Mar 25. J Am Nutr Assoc. 2023. PMID: 35512774 Clinical Trial.