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Page 1
PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis.
Kuttke M, Hromadová D, Yildirim C, Brunner JS, Vogel A, Paar H, Peters S, Weber M, Hofmann M, Kerndl M, Kieler M, Datler H, Musiejovsky L, Salzmann M, Lang M, Soukup K, Halfmann A, Sharif O, Schabbauer G. Kuttke M, et al. Among authors: kerndl m. Front Immunol. 2022 Apr 19;13:695576. doi: 10.3389/fimmu.2022.695576. eCollection 2022. Front Immunol. 2022. PMID: 35514976 Free PMC article.
PI3K activity in dendritic cells exerts paradoxical effects during autoimmune inflammation.
Datler H, Vogel A, Kerndl M, Baumgartinger C, Musiejovsky L, Makivic N, Frech S, Niederreiter B, Haider T, Pühringer M, Brunner JS, Sharif O, Schabbauer G. Datler H, et al. Among authors: kerndl m. Mol Immunol. 2019 Jul;111:32-42. doi: 10.1016/j.molimm.2019.03.015. Epub 2019 Apr 5. Mol Immunol. 2019. PMID: 30959419 Free article.
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.
Vogel A, Martin K, Soukup K, Halfmann A, Kerndl M, Brunner JS, Hofmann M, Oberbichler L, Korosec A, Kuttke M, Datler H, Kieler M, Musiejovsky L, Dohnal A, Sharif O, Schabbauer G. Vogel A, et al. Among authors: kerndl m. Cell Rep. 2022 Feb 22;38(8):110420. doi: 10.1016/j.celrep.2022.110420. Cell Rep. 2022. PMID: 35196494 Free article.
The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. Brunner JS, et al. Among authors: kerndl m. Nat Metab. 2020 Dec;2(12):1427-1442. doi: 10.1038/s42255-020-00311-5. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199895
Environmental arginine controls multinuclear giant cell metabolism and formation.
Brunner JS, Vulliard L, Hofmann M, Kieler M, Lercher A, Vogel A, Russier M, Brüggenthies JB, Kerndl M, Saferding V, Niederreiter B, Junza A, Frauenstein A, Scholtysek C, Mikami Y, Klavins K, Krönke G, Bergthaler A, O'Shea JJ, Weichhart T, Meissner F, Smolen JS, Cheng P, Yanes O, Menche J, Murray PJ, Sharif O, Blüml S, Schabbauer G. Brunner JS, et al. Among authors: kerndl m. Nat Commun. 2020 Jan 22;11(1):431. doi: 10.1038/s41467-020-14285-1. Nat Commun. 2020. PMID: 31969567 Free PMC article.
Itaconate confers tolerance to late NLRP3 inflammasome activation.
Bambouskova M, Potuckova L, Paulenda T, Kerndl M, Mogilenko DA, Lizotte K, Swain A, Hayes S, Sheldon RD, Kim H, Kapadnis U, Ellis AE, Isaguirre C, Burdess S, Laha A, Amarasinghe GK, Chubukov V, Roddy TP, Diamond MS, Jones RG, Simons DM, Artyomov MN. Bambouskova M, et al. Among authors: kerndl m. Cell Rep. 2021 Mar 9;34(10):108756. doi: 10.1016/j.celrep.2021.108756. Cell Rep. 2021. PMID: 33691097 Free PMC article.
Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging.
Mogilenko DA, Shpynov O, Andhey PS, Arthur L, Swain A, Esaulova E, Brioschi S, Shchukina I, Kerndl M, Bambouskova M, Yao Z, Laha A, Zaitsev K, Burdess S, Gillfilan S, Stewart SA, Colonna M, Artyomov MN. Mogilenko DA, et al. Among authors: kerndl m. Immunity. 2021 Jan 12;54(1):99-115.e12. doi: 10.1016/j.immuni.2020.11.005. Epub 2020 Dec 2. Immunity. 2021. PMID: 33271118 Free article.
UDP-sulfoquinovose formation by Sulfolobus acidocaldarius.
Zolghadr B, Gasselhuber B, Windwarder M, Pabst M, Kracher D, Kerndl M, Zayni S, Hofinger-Horvath A, Ludwig R, Haltrich D, Oostenbrink C, Obinger C, Kosma P, Messner P, Schäffer C. Zolghadr B, et al. Among authors: kerndl m. Extremophiles. 2015 Mar;19(2):451-67. doi: 10.1007/s00792-015-0730-9. Epub 2015 Jan 21. Extremophiles. 2015. PMID: 25605538 Free PMC article.
Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis.
Kieler M, Prammer LS, Heller G, Hofmann M, Sperger S, Hanetseder D, Niederreiter B, Komljenovic A, Klavins K, Köcher T, Brunner JS, Stanic I, Oberbichler L, Korosec A, Vogel A, Kerndl M, Hromadová D, Musiejovsky L, Hajto A, Dobrijevic A, Piwonka T, Haschemi A, Miller A, Georgel P, Marolt Presen D, Grillari J, Hayer S, Auger JP, Krönke G, Sharif O, Aletaha D, Schabbauer G, Blüml S. Kieler M, et al. Among authors: kerndl m. Ann Rheum Dis. 2024 Oct 21;83(11):1465-1479. doi: 10.1136/ard-2023-224898. Ann Rheum Dis. 2024. PMID: 38986577 Free PMC article.