Ihara K - Search Results

1

Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery.

Dileep KV, Ihara K, Mishima-Tsumagari C, Kukimoto-Niino M, Yonemochi M, Hanada K, Shirouzu M, Zhang KYJ. Dileep KV, et al. Among authors: ihara k. Int J Biol Macromol. 2022 Jun 15;210:172-181. doi: 10.1016/j.ijbiomac.2022.05.009. Epub 2022 May 6. Int J Biol Macromol. 2022. PMID: 35526766

2

Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.

Kukimoto-Niino M, Tsuda K, Ihara K, Mishima-Tsumagari C, Honda K, Ohsawa N, Shirouzu M. Kukimoto-Niino M, et al. Among authors: ihara k. Structure. 2019 May 7;27(5):741-748.e3. doi: 10.1016/j.str.2019.02.001. Epub 2019 Mar 7. Structure. 2019. PMID: 30853411 Free article.

3

Isoprenoid-chained lipid EROCOC₁₇₊₄: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography.

Ihara K, Hato M, Nakane T, Yamashita K, Kimura-Someya T, Hosaka T, Ishizuka-Katsura Y, Tanaka R, Tanaka T, Sugahara M, Hirata K, Yamamoto M, Nureki O, Tono K, Nango E, Iwata S, Shirouzu M. Ihara K, et al. Sci Rep. 2020 Nov 9;10(1):19305. doi: 10.1038/s41598-020-76277-x. Sci Rep. 2020. PMID: 33168855 Free PMC article.

4

Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors.

Dileep KV, Sakai N, Ihara K, Kato-Murayama M, Nakata A, Ito A, Sivaraman DM, Shin JW, Yoshida M, Shirouzu M, Zhang KYJ. Dileep KV, et al. Among authors: ihara k. Int J Biol Macromol. 2021 Feb 15;170:415-423. doi: 10.1016/j.ijbiomac.2020.12.118. Epub 2020 Dec 27. Int J Biol Macromol. 2021. PMID: 33373636

5

Structural insights into the small GTPase specificity of the DOCK guanine nucleotide exchange factors.

Kukimoto-Niino M, Ihara K, Murayama K, Shirouzu M. Kukimoto-Niino M, et al. Among authors: ihara k. Curr Opin Struct Biol. 2021 Dec;71:249-258. doi: 10.1016/j.sbi.2021.08.001. Epub 2021 Sep 8. Curr Opin Struct Biol. 2021. PMID: 34507037 Review.

6

Conformational alterations in unidirectional ion transport of a light-driven chloride pump revealed using X-ray free electron lasers.

Hosaka T, Nomura T, Kubo M, Nakane T, Fangjia L, Sekine SI, Ito T, Murayama K, Ihara K, Ehara H, Kashiwagi K, Katsura K, Akasaka R, Hisano T, Tanaka T, Tanaka R, Arima T, Yamashita A, Sugahara M, Naitow H, Matsuura Y, Yoshizawa S, Tono K, Owada S, Nureki O, Kimura-Someya T, Iwata S, Nango E, Shirouzu M. Hosaka T, et al. Among authors: ihara k. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2117433119. doi: 10.1073/pnas.2117433119. Proc Natl Acad Sci U S A. 2022. PMID: 35197289 Free PMC article.

7

Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.

Kukimoto-Niino M, Ihara K, Mishima-Tsumagari C, Inoue M, Fukui Y, Yokoyama S, Shirouzu M. Kukimoto-Niino M, et al. Among authors: ihara k. Biochem Biophys Res Commun. 2023 Apr 23;653:12-20. doi: 10.1016/j.bbrc.2023.02.054. Epub 2023 Feb 21. Biochem Biophys Res Commun. 2023. PMID: 36848820

8

Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.

Ihara K, Muraguchi S, Kato M, Shimizu T, Shirakawa M, Kuroda S, Kaibuchi K, Hakoshima T. Ihara K, et al. J Biol Chem. 1998 Apr 17;273(16):9656-66. doi: 10.1074/jbc.273.16.9656. J Biol Chem. 1998. PMID: 9545299 Free article.

9

An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism.

Shimizu T, Ihara K, Maesaki R, Kuroda S, Kaibuchi K, Hakoshima T. Shimizu T, et al. Among authors: ihara k. J Biol Chem. 2000 Jun 16;275(24):18311-7. doi: 10.1074/jbc.M910274199. J Biol Chem. 2000. PMID: 10748207 Free article.

10

The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.

Maesaki R, Ihara K, Shimizu T, Kuroda S, Kaibuchi K, Hakoshima T. Maesaki R, et al. Among authors: ihara k. Mol Cell. 1999 Nov;4(5):793-803. doi: 10.1016/s1097-2765(00)80389-5. Mol Cell. 1999. PMID: 10619026 Free article.

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