Meng L - Search Results

1

Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy.

Zhang X, Wang Y, Meng L. Zhang X, et al. Among authors: meng l. Acta Pharm Sin B. 2022 Mar;12(3):1054-1067. doi: 10.1016/j.apsb.2021.09.028. Epub 2021 Sep 30. Acta Pharm Sin B. 2022. PMID: 35530133 Free PMC article. Review.

2

PI3K isoform-selective inhibitors: next-generation targeted cancer therapies.

Wang X, Ding J, Meng LH. Wang X, et al. Acta Pharmacol Sin. 2015 Oct;36(10):1170-6. doi: 10.1038/aps.2015.71. Epub 2015 Sep 14. Acta Pharmacol Sin. 2015. PMID: 26364801 Free PMC article. Review.

3

Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3Kα-selective inhibitor CYH33 in breast cancer.

Liu XL, Xu YC, Wang YX, Chen Y, Wang BB, Wang Y, Chen YH, Tan C, Hu LD, Ma QY, Zhang YC, Sun YM, Gao YL, Yang CH, Ding J, Meng LH. Liu XL, et al. Cancer Lett. 2018 Oct 1;433:273-282. doi: 10.1016/j.canlet.2018.07.011. Epub 2018 Jul 9. Cancer Lett. 2018. PMID: 30003928

4

Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA^H1047R accompanied with pro-tumorigenic secretome.

Liu XL, Liu JL, Xu YC, Zhang X, Wang YX, Qing LH, Guo W, Ding J, Meng LH. Liu XL, et al. Int J Cancer. 2019 Aug 1;145(3):817-829. doi: 10.1002/ijc.32153. Epub 2019 Feb 7. Int J Cancer. 2019. PMID: 30671946

5

Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer.

Wang Y, Li X, Liu X, Chen Y, Yang C, Tan C, Wang B, Sun Y, Zhang X, Gao Y, Ding J, Meng L. Wang Y, et al. Among authors: meng l. Cancer Biol Med. 2019 Feb;16(1):66-83. doi: 10.20892/j.issn.2095-3941.2018.0361. Cancer Biol Med. 2019. PMID: 31119047 Free PMC article.

6

Polycyclic polyprenylated acylphloroglucinols from Hypericum choisianum.

Zhang HB, Zhang X, Jiang K, Qu SJ, Meng LH, Lu Q, Tan CH. Zhang HB, et al. Nat Prod Res. 2021 Jan;35(2):195-202. doi: 10.1080/14786419.2019.1619723. Epub 2019 May 31. Nat Prod Res. 2021. PMID: 31148477

7

Design, synthesis, and biological activity evaluation of (-)-6-O-desmethylantofine analogues as potent anti-cancer agents.

Han G, Qing L, Wu M, Wang Y, Liu Y, Liu X, Wang Z, Ding J, Meng LH, Wang Q. Han G, et al. Among authors: meng lh. Bioorg Med Chem. 2019 Jul 15;27(14):3070-3081. doi: 10.1016/j.bmc.2019.05.030. Epub 2019 May 21. Bioorg Med Chem. 2019. PMID: 31171403

8

PI3Kα inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment.

Shi JJ, Xing H, Wang YX, Zhang X, Zhan QM, Geng MY, Ding J, Meng LH. Shi JJ, et al. Cancer Lett. 2019 Sep 10;459:145-155. doi: 10.1016/j.canlet.2019.05.040. Epub 2019 Jun 4. Cancer Lett. 2019. PMID: 31173854

9

CRISPR-cas9: a powerful tool towards precision medicine in cancer treatment.

Xing H, Meng LH. Xing H, et al. Acta Pharmacol Sin. 2020 May;41(5):583-587. doi: 10.1038/s41401-019-0322-9. Epub 2019 Dec 2. Acta Pharmacol Sin. 2020. PMID: 31792341 Free PMC article. Review.

10

Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer.

Liu XL, Wang BB, Wang Y, Wang YX, Yang CH, Tan C, Zhang X, He QJ, Ding J, Meng LH. Liu XL, et al. Signal Transduct Target Ther. 2019 Nov 22;4:49. doi: 10.1038/s41392-019-0085-2. eCollection 2019. Signal Transduct Target Ther. 2019. PMID: 31798976 Free PMC article. No abstract available.

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