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Page 1
Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain.
Latorre R, Ramírez-Garcia PD, Hegron A, Grace JL, Retamal JS, Shenoy P, Tran M, Aurelio L, Flynn B, Poole DP, Klein-Cloud R, Jensen DD, Davis TP, Schmidt BL, Quinn JF, Whittaker MR, Veldhuis NA, Bunnett NW. Latorre R, et al. Biomaterials. 2022 Jun;285:121536. doi: 10.1016/j.biomaterials.2022.121536. Epub 2022 Apr 28. Biomaterials. 2022. PMID: 35533442 Free PMC article.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW. Jimenez-Vargas NN, et al. Among authors: latorre r. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012612 Free PMC article.
Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.
Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG. Israelyan N, et al. Among authors: latorre r. Gastroenterology. 2019 Aug;157(2):507-521.e4. doi: 10.1053/j.gastro.2019.04.022. Epub 2019 May 7. Gastroenterology. 2019. PMID: 31071306 Free PMC article.
A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain.
Ramírez-García PD, Retamal JS, Shenoy P, Imlach W, Sykes M, Truong N, Constandil L, Pelissier T, Nowell CJ, Khor SY, Layani LM, Lumb C, Poole DP, Lieu T, Stewart GD, Mai QN, Jensen DD, Latorre R, Scheff NN, Schmidt BL, Quinn JF, Whittaker MR, Veldhuis NA, Davis TP, Bunnett NW. Ramírez-García PD, et al. Among authors: latorre r. Nat Nanotechnol. 2019 Dec;14(12):1150-1159. doi: 10.1038/s41565-019-0568-x. Epub 2019 Nov 4. Nat Nanotechnol. 2019. PMID: 31686009 Free PMC article.
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain.
Jimenez-Vargas NN, Gong J, Wisdom MJ, Jensen DD, Latorre R, Hegron A, Teng S, DiCello JJ, Rajasekhar P, Veldhuis NA, Carbone SE, Yu Y, Lopez-Lopez C, Jaramillo-Polanco J, Canals M, Reed DE, Lomax AE, Schmidt BL, Leong KW, Vanner SJ, Halls ML, Bunnett NW, Poole DP. Jimenez-Vargas NN, et al. Among authors: latorre r. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15281-15292. doi: 10.1073/pnas.2000500117. Epub 2020 Jun 16. Proc Natl Acad Sci U S A. 2020. PMID: 32546520 Free PMC article.
Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects.
Jiménez-Vargas NN, Yu Y, Jensen DD, Bok DD, Wisdom M, Latorre R, Lopez C, Jaramillo-Polanco JO, Degro C, Guzman-Rodriguez M, Tsang Q, Snow Z, Schmidt BL, Reed DE, Lomax AE, Margolis KG, Stein C, Bunnett NW, Vanner SJ. Jiménez-Vargas NN, et al. Among authors: latorre r. Gut. 2022 Apr;71(4):695-704. doi: 10.1136/gutjnl-2021-324070. Epub 2021 Mar 30. Gut. 2022. PMID: 33785555 Free PMC article.
Cathepsin S Evokes PAR2-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models.
Tu NH, Inoue K, Chen E, Anderson BM, Sawicki CM, Scheff NN, Tran HD, Kim DH, Alemu RG, Yang L, Dolan JC, Liu CZ, Janal MN, Latorre R, Jensen DD, Bunnett NW, Edgington-Mitchell LE, Schmidt BL. Tu NH, et al. Among authors: latorre r. Cancers (Basel). 2021 Sep 19;13(18):4697. doi: 10.3390/cancers13184697. Cancers (Basel). 2021. PMID: 34572924 Free PMC article.
Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain.
Latorre R, Hegron A, Peach CJ, Teng S, Tonello R, Retamal JS, Klein-Cloud R, Bok D, Jensen DD, Gottesman-Katz L, Rientjes J, Veldhuis NA, Poole DP, Schmidt BL, Pothoulakis CH, Rankin C, Xie Y, Koon HW, Bunnett NW. Latorre R, et al. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2112059119. doi: 10.1073/pnas.2112059119. Proc Natl Acad Sci U S A. 2022. PMID: 35110404 Free PMC article.
389 results