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Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy.
Zhang D, Reyes RM, Osta E, Kari S, Gupta HB, Padron AS, Kornepati AVR, Kancharla A, Sun X, Deng Y, Wu B, Vadlamudi R, Li R, Svatek RS, Curiel TJ. Zhang D, et al. Among authors: kornepati avr. Cancer Med. 2021 Mar;10(6):2137-2152. doi: 10.1002/cam4.3739. Epub 2021 Feb 24. Cancer Med. 2021. PMID: 33626233 Free PMC article.
CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδ T cell activation.
Reyes RM, Deng Y, Zhang D, Ji N, Mukherjee N, Wheeler K, Gupta HB, Padron AS, Kancharla A, Zhang C, Garcia M, Kornepati AVR, Boyman O, Conejo-Garcia JR, Svatek RS, Curiel TJ. Reyes RM, et al. Among authors: kornepati avr. J Immunother Cancer. 2021 Apr;9(4):e002051. doi: 10.1136/jitc-2020-002051. J Immunother Cancer. 2021. PMID: 33849925 Free PMC article.
Programmed death ligand 1 signals in cancer cells.
Kornepati AVR, Vadlamudi RK, Curiel TJ. Kornepati AVR, et al. Nat Rev Cancer. 2022 Mar;22(3):174-189. doi: 10.1038/s41568-021-00431-4. Epub 2022 Jan 14. Nat Rev Cancer. 2022. PMID: 35031777 Free PMC article. Review.
Tumor Intrinsic PD-L1 Promotes DNA Repair in Distinct Cancers and Suppresses PARP Inhibitor-Induced Synthetic Lethality.
Kornepati AVR, Boyd JT, Murray CE, Saifetiarova J, de la Peña Avalos B, Rogers CM, Bai H, Padron AS, Liao Y, Ontiveros C, Svatek RS, Hromas R, Li R, Hu Y, Conejo-Garcia JR, Vadlamudi RK, Zhao W, Dray E, Sung P, Curiel TJ. Kornepati AVR, et al. Cancer Res. 2022 Jun 6;82(11):2156-2170. doi: 10.1158/0008-5472.CAN-21-2076. Cancer Res. 2022. PMID: 35247877 Free PMC article.
Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects.
Bai H, Padron AS, Deng Y, Liao YJ, Murray CJ, Ontiveros C, Kari SJ, Kancharla A, Kornepati AVR, Garcia M, Reyes RM, Gupta HB, Conejo-Garcia JR, Curiel T. Bai H, et al. Among authors: kornepati avr. J Immunother Cancer. 2023 Feb;11(2):e004871. doi: 10.1136/jitc-2022-004871. J Immunother Cancer. 2023. PMID: 36759012 Free PMC article.
21 results