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SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel.
Wu T, Goriounova AS, Worthington EN, Wrennall JA, Ghosh A, Ahmad S, Flori Sassano M, Tarran R. Wu T, et al. Among authors: goriounova as. Physiol Rep. 2022 May;10(10):e15306. doi: 10.14814/phy2.15306. Physiol Rep. 2022. PMID: 35581745 Free PMC article.
Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an Acute Respiratory Distress Syndrome Model.
Ahmad S, Wrennall JA, Goriounova AS, Sekhri M, Iskarpatyoti JA, Ghosh A, Abdelwahab SH, Voeller A, Rai M, Mahida RY, Krajewski K, Ignar DM, Greenbaum A, Moran TP, Tilley SL, Thickett DR, Sassano MF, Tarran R. Ahmad S, et al. Among authors: goriounova as. Am J Respir Crit Care Med. 2024 Mar 15;209(6):703-715. doi: 10.1164/rccm.202308-1393OC. Am J Respir Crit Care Med. 2024. PMID: 37972349