Krainer AR - Search Results

1

Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy.

Kim YJ, Nomakuchi T, Papaleonidopoulou F, Yang L, Zhang Q, Krainer AR. Kim YJ, et al. Among authors: krainer ar. Nat Commun. 2022 May 27;13(1):2978. doi: 10.1038/s41467-022-30668-y. Nat Commun. 2022. PMID: 35624092 Free PMC article.

2

A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes.

Liu HX, Cartegni L, Zhang MQ, Krainer AR. Liu HX, et al. Among authors: krainer ar. Nat Genet. 2001 Jan;27(1):55-8. doi: 10.1038/83762. Nat Genet. 2001. PMID: 11137998

3

Listening to silence and understanding nonsense: exonic mutations that affect splicing.

Cartegni L, Chew SL, Krainer AR. Cartegni L, et al. Among authors: krainer ar. Nat Rev Genet. 2002 Apr;3(4):285-98. doi: 10.1038/nrg775. Nat Rev Genet. 2002. PMID: 11967553 Review.

4

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model.

Hua Y, Sahashi K, Rigo F, Hung G, Horev G, Bennett CF, Krainer AR. Hua Y, et al. Among authors: krainer ar. Nature. 2011 Oct 5;478(7367):123-6. doi: 10.1038/nature10485. Nature. 2011. PMID: 21979052 Free PMC article.

5

Pathological impact of SMN2 mis-splicing in adult SMA mice.

Sahashi K, Ling KK, Hua Y, Wilkinson JE, Nomakuchi T, Rigo F, Hung G, Xu D, Jiang YP, Lin RZ, Ko CP, Bennett CF, Krainer AR. Sahashi K, et al. Among authors: krainer ar. EMBO Mol Med. 2013 Oct;5(10):1586-601. doi: 10.1002/emmm.201302567. Epub 2013 Sep 9. EMBO Mol Med. 2013. PMID: 24014320 Free PMC article.

6

Antisense oligonucleotide-directed inhibition of nonsense-mediated mRNA decay.

Nomakuchi TT, Rigo F, Aznarez I, Krainer AR. Nomakuchi TT, et al. Among authors: krainer ar. Nat Biotechnol. 2016 Feb;34(2):164-6. doi: 10.1038/nbt.3427. Epub 2015 Dec 14. Nat Biotechnol. 2016. PMID: 26655495 Free PMC article.

7

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.

Sivaramakrishnan M, McCarthy KD, Campagne S, Huber S, Meier S, Augustin A, Heckel T, Meistermann H, Hug MN, Birrer P, Moursy A, Khawaja S, Schmucki R, Berntenis N, Giroud N, Golling S, Tzouros M, Banfai B, Duran-Pacheco G, Lamerz J, Hsiu Liu Y, Luebbers T, Ratni H, Ebeling M, Cléry A, Paushkin S, Krainer AR, Allain FH, Metzger F. Sivaramakrishnan M, et al. Among authors: krainer ar. Nat Commun. 2017 Nov 14;8(1):1476. doi: 10.1038/s41467-017-01559-4. Nat Commun. 2017. PMID: 29133793 Free PMC article.

8

Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice.

Sinha R, Kim YJ, Nomakuchi T, Sahashi K, Hua Y, Rigo F, Bennett CF, Krainer AR. Sinha R, et al. Among authors: krainer ar. Nucleic Acids Res. 2018 Jun 1;46(10):4833-4844. doi: 10.1093/nar/gky249. Nucleic Acids Res. 2018. PMID: 29672717 Free PMC article.

9

Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1.

Aznarez I, Nomakuchi TT, Tetenbaum-Novatt J, Rahman MA, Fregoso O, Rees H, Krainer AR. Aznarez I, et al. Among authors: krainer ar. Cell Rep. 2018 May 15;23(7):2186-2198. doi: 10.1016/j.celrep.2018.04.039. Cell Rep. 2018. PMID: 29768215 Free PMC article.

10

Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides.

Scharner J, Ma WK, Zhang Q, Lin KT, Rigo F, Bennett CF, Krainer AR. Scharner J, et al. Among authors: krainer ar. Nucleic Acids Res. 2020 Jan 24;48(2):802-816. doi: 10.1093/nar/gkz1132. Nucleic Acids Res. 2020. PMID: 31802121 Free PMC article.

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