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Author Correction: A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals.
Liu P, Smith BR, Montonye ML, Kemper LJ, Leinonen-Wright K, Nelson KM, Higgins L, Guerrero CR, Markowski TW, Zhao X, Petersen AJ, Knopman DS, Petersen RC, Ashe KH. Liu P, et al. Among authors: ashe kh. Sci Rep. 2020 May 12;10(1):8077. doi: 10.1038/s41598-020-65178-8. Sci Rep. 2020. PMID: 32398746 Free PMC article.
Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
Bresinsky M, Strasser JM, Vallaster B, Liu P, McCue WM, Fuller J, Hubmann A, Singh G, Nelson KM, Cuellar ME, Wilmot CM, Finzel BC, Ashe KH, Walters MA, Pockes S. Bresinsky M, et al. Among authors: ashe kh. ACS Pharmacol Transl Sci. 2022 Jan 5;5(1):20-40. doi: 10.1021/acsptsci.1c00251. eCollection 2022 Jan 14. ACS Pharmacol Transl Sci. 2022. PMID: 35059567 Free PMC article.
Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy.
Singh G, Liu P, Yao KR, Strasser JM, Hlynialuk C, Leinonen-Wright K, Teravskis PJ, Choquette JM, Ikramuddin J, Bresinsky M, Nelson KM, Liao D, Ashe KH, Walters MA, Pockes S. Singh G, et al. Among authors: ashe kh. ACS Chem Neurosci. 2022 May 18;13(10):1549-1557. doi: 10.1021/acschemneuro.2c00100. Epub 2022 May 6. ACS Chem Neurosci. 2022. PMID: 35522720 Free PMC article.
Accumulation of pTau231 at the Postsynaptic Density in Early Alzheimer's Disease.
Lilek J, Ajroud K, Feldman AZ, Krishnamachari S, Ghourchian S, Gefen T, Spencer CL, Kawles A, Mao Q, Tranovich JF, Jack CR, Mesulam MM, Reichard RR, Zhang H, Murray ME, Knopman D, Dickson DW, Petersen RC, Smith B, Ashe KH, Mielke MM, Nelson KM, Flanagan ME. Lilek J, et al. Among authors: ashe kh. J Alzheimers Dis. 2023;92(1):241-260. doi: 10.3233/JAD-220848. J Alzheimers Dis. 2023. PMID: 36744338 Free PMC article.
Caspase-2 cleavage of tau reversibly impairs memory.
Zhao X, Kotilinek LA, Smith B, Hlynialuk C, Zahs K, Ramsden M, Cleary J, Ashe KH. Zhao X, et al. Among authors: ashe kh. Nat Med. 2016 Nov;22(11):1268-1276. doi: 10.1038/nm.4199. Epub 2016 Oct 10. Nat Med. 2016. PMID: 27723722
85 results