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Page 1
Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.
Panicker N, Kam TI, Wang H, Neifert S, Chou SC, Kumar M, Brahmachari S, Jhaldiyal A, Hinkle JT, Akkentli F, Mao X, Xu E, Karuppagounder SS, Hsu ET, Kang SU, Pletnikova O, Troncoso J, Dawson VL, Dawson TM. Panicker N, et al. Among authors: kam ti. Neuron. 2022 Aug 3;110(15):2422-2437.e9. doi: 10.1016/j.neuron.2022.05.009. Epub 2022 Jun 1. Neuron. 2022. PMID: 35654037 Free PMC article.
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.
Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM. Mao X, et al. Among authors: kam ti. Science. 2016 Sep 30;353(6307):aah3374. doi: 10.1126/science.aah3374. Science. 2016. PMID: 27708076 Free PMC article.
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.
Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam TI, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S, Zhu H, Song H, Ming GL, Dawson VL, Dawson TM. Wang Y, et al. Among authors: kam ti. Science. 2016 Oct 7;354(6308):aad6872. doi: 10.1126/science.aad6872. Science. 2016. PMID: 27846469 Free PMC article.
PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.
Lee Y, Stevens DA, Kang SU, Jiang H, Lee YI, Ko HS, Scarffe LA, Umanah GE, Kang H, Ham S, Kam TI, Allen K, Brahmachari S, Kim JW, Neifert S, Yun SP, Fiesel FC, Springer W, Dawson VL, Shin JH, Dawson TM. Lee Y, et al. Among authors: kam ti. Cell Rep. 2017 Jan 24;18(4):918-932. doi: 10.1016/j.celrep.2016.12.090. Cell Rep. 2017. PMID: 28122242 Free PMC article.
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.
Yun SP, Kam TI, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, Kang SU, Lee Y, Lee KC, Na DH, Kim D, Lee SH, Roschke VV, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S, Dawson TM, Ko HS. Yun SP, et al. Among authors: kam ti. Nat Med. 2018 Jul;24(7):931-938. doi: 10.1038/s41591-018-0051-5. Epub 2018 Jun 11. Nat Med. 2018. PMID: 29892066 Free PMC article.
Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.
Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL. Kam TI, et al. Science. 2018 Nov 2;362(6414):eaat8407. doi: 10.1126/science.aat8407. Science. 2018. PMID: 30385548 Free PMC article.
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.
Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A. Panicker N, et al. Among authors: kam ti. J Exp Med. 2019 Jun 3;216(6):1411-1430. doi: 10.1084/jem.20182191. Epub 2019 Apr 29. J Exp Med. 2019. PMID: 31036561 Free PMC article.
47 results