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Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques.
Nouën CL, Nelson CE, Liu X, Park HS, Matsuoka Y, Luongo C, Santos C, Yang L, Herbert R, Castens A, Moore IN, Wilder-Kofie T, Moore R, Walker A, Zhang P, Lusso P, Johnson RF, Garza NL, Via LE, Munir S, Barber D, Buchholz UJ. Nouën CL, et al. Among authors: luongo c. bioRxiv [Preprint]. 2022 May 23:2022.05.21.492923. doi: 10.1101/2022.05.21.492923. bioRxiv. 2022. Update in: Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2109744118. doi: 10.1073/pnas.2109744118 PMID: 35665011 Free PMC article. Updated. Preprint.
Respiratory syncytial virus modified by deletions of the NS2 gene and amino acid S1313 of the L polymerase protein is a temperature-sensitive, live-attenuated vaccine candidate that is phenotypically stable at physiological temperature.
Luongo C, Winter CC, Collins PL, Buchholz UJ. Luongo C, et al. J Virol. 2013 Feb;87(4):1985-96. doi: 10.1128/JVI.02769-12. Epub 2012 Dec 12. J Virol. 2013. PMID: 23236065 Free PMC article.
In previous work to develop point mutations in RSV with improved genetic stability, we observed that an attenuating mutation at amino acid position 1321 in the L polymerase protein was subject to deattenuation by a spontaneous second-site compensatory mutation at position 1313 ( …
In previous work to develop point mutations in RSV with improved genetic stability, we observed that an attenuating mutation at amino acid p …
Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization.
Le Nouën C, Brock LG, Luongo C, McCarty T, Yang L, Mehedi M, Wimmer E, Mueller S, Collins PL, Buchholz UJ, DiNapoli JM. Le Nouën C, et al. Among authors: luongo c. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13169-74. doi: 10.1073/pnas.1411290111. Epub 2014 Aug 25. Proc Natl Acad Sci U S A. 2014. PMID: 25157129 Free PMC article.
Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure.
Le Nouën C, McCarty T, Brown M, Smith ML, Lleras R, Dolan MA, Mehedi M, Yang L, Luongo C, Liang B, Munir S, DiNapoli JM, Mueller S, Wimmer E, Collins PL, Buchholz UJ. Le Nouën C, et al. Among authors: luongo c. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E386-E395. doi: 10.1073/pnas.1619242114. Epub 2017 Jan 3. Proc Natl Acad Sci U S A. 2017. PMID: 28049853 Free PMC article.
180 results