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Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.
Hertzog J, Zhou W, Fowler G, Rigby RE, Bridgeman A, Blest HT, Cursi C, Chauveau L, Davenne T, Warner BE, Kinchington PR, Kranzusch PJ, Rehwinkel J. Hertzog J, et al. Among authors: rigby re. EMBO J. 2022 Jul 18;41(14):e109217. doi: 10.15252/embj.2021109217. Epub 2022 Jun 7. EMBO J. 2022. PMID: 35670106 Free PMC article.
Deoxyguanosine is a TLR7 agonist.
Davenne T, Bridgeman A, Rigby RE, Rehwinkel J. Davenne T, et al. Among authors: rigby re. Eur J Immunol. 2020 Jan;50(1):56-62. doi: 10.1002/eji.201948151. Epub 2019 Nov 14. Eur J Immunol. 2020. PMID: 31608988 Free PMC article.
RNA degradation in antiviral immunity and autoimmunity.
Rigby RE, Rehwinkel J. Rigby RE, et al. Trends Immunol. 2015 Mar;36(3):179-88. doi: 10.1016/j.it.2015.02.001. Epub 2015 Feb 20. Trends Immunol. 2015. PMID: 25709093 Free PMC article. Review.
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.
Hertzog J, Dias Junior AG, Rigby RE, Donald CL, Mayer A, Sezgin E, Song C, Jin B, Hublitz P, Eggeling C, Kohl A, Rehwinkel J. Hertzog J, et al. Among authors: rigby re. Eur J Immunol. 2018 Jul;48(7):1120-1136. doi: 10.1002/eji.201847483. Epub 2018 Apr 6. Eur J Immunol. 2018. PMID: 29572905 Free PMC article.
SAMHD1-dependent retroviral control and escape in mice.
Rehwinkel J, Maelfait J, Bridgeman A, Rigby R, Hayward B, Liberatore RA, Bieniasz PD, Towers GJ, Moita LF, Crow YJ, Bonthron DT, Reis e Sousa C. Rehwinkel J, et al. EMBO J. 2013 Sep 11;32(18):2454-62. doi: 10.1038/emboj.2013.163. Epub 2013 Jul 19. EMBO J. 2013. PMID: 23872947 Free PMC article.
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK. Hansen AL, et al. Among authors: rigby re. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7768-E7775. doi: 10.1073/pnas.1806239115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061387 Free PMC article.
19 results