Gosens R - Search Results

1

Differential roles for lysyl oxidase (like), family members in chronic obstructive pulmonary disease; from gene and protein expression to function.

Migulina N, Tjin G, Faiz A, Borghuis T, Zhao F, Kaper HJ, Metzlar M, van Dijk E, Sharma PK, Timens W, Gosens R, Brandsma CA, Burgess JK. Migulina N, et al. Among authors: gosens r. FASEB J. 2022 Jul;36(7):e22374. doi: 10.1096/fj.202101553R. FASEB J. 2022. PMID: 35670745

2

Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease.

Baarsma HA, Spanjer AI, Haitsma G, Engelbertink LH, Meurs H, Jonker MR, Timens W, Postma DS, Kerstjens HA, Gosens R. Baarsma HA, et al. Among authors: gosens r. PLoS One. 2011;6(9):e25450. doi: 10.1371/journal.pone.0025450. Epub 2011 Sep 30. PLoS One. 2011. PMID: 21980461 Free PMC article.

3

Glycogen synthase kinase-3 (GSK-3) regulates TGF-β₁-induced differentiation of pulmonary fibroblasts.

Baarsma HA, Engelbertink LH, van Hees LJ, Menzen MH, Meurs H, Timens W, Postma DS, Kerstjens HA, Gosens R. Baarsma HA, et al. Among authors: gosens r. Br J Pharmacol. 2013 Jun;169(3):590-603. doi: 10.1111/bph.12098. Br J Pharmacol. 2013. PMID: 23297769 Free PMC article.

4

Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease.

Heijink IH, de Bruin HG, van den Berge M, Bennink LJ, Brandenburg SM, Gosens R, van Oosterhout AJ, Postma DS. Heijink IH, et al. Among authors: gosens r. Thorax. 2013 Aug;68(8):709-16. doi: 10.1136/thoraxjnl-2012-201667. Epub 2013 Jan 31. Thorax. 2013. PMID: 23370438

5

Airway Smooth Muscle and Fibroblast Biology still a leading research focus for Young Investigators in the field.

Burgess JK, Gosens R. Burgess JK, et al. Among authors: gosens r. Pulm Pharmacol Ther. 2014 Dec;29(2):91-2. doi: 10.1016/j.pupt.2014.08.003. Epub 2014 Aug 23. Pulm Pharmacol Ther. 2014. PMID: 25183686 No abstract available.

6

Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.

Jansen SR, Holman R, Hedemann I, Frankes E, Elzinga CR, Timens W, Gosens R, de Bont ES, Schmidt M. Jansen SR, et al. Among authors: gosens r. J Cell Mol Med. 2015 Jan;19(1):210-26. doi: 10.1111/jcmm.12418. Epub 2014 Sep 30. J Cell Mol Med. 2015. PMID: 25266063 Free PMC article.

7

A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.

Spanjer AI, Menzen MH, Dijkstra AE, van den Berge M, Boezen HM, Nickle DC, Sin DD, Bossé Y, Brandsma CA, Timens W, Postma DS, Meurs H, Heijink IH, Gosens R. Spanjer AI, et al. Among authors: gosens r. Thorax. 2016 Apr;71(4):312-22. doi: 10.1136/thoraxjnl-2015-206958. Epub 2016 Jan 21. Thorax. 2016. PMID: 26797711

8

TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8.

Spanjer AI, Baarsma HA, Oostenbrink LM, Jansen SR, Kuipers CC, Lindner M, Postma DS, Meurs H, Heijink IH, Gosens R, Königshoff M. Spanjer AI, et al. Among authors: gosens r. FASEB J. 2016 May;30(5):1823-35. doi: 10.1096/fj.201500129. Epub 2016 Feb 5. FASEB J. 2016. PMID: 26849959

Collectively, our findings demonstrate a role for FZD8 in TGF-beta-induced profibrotic signaling and imply that WNT-5B may be the ligand for FZD8 in these responses.-Spanjer, A. I. R., Baarsma, H. A., Oostenbrink, L. M., Jansen, S. R., Kuipers, C. C., Lindner, M., P …

Collectively, our findings demonstrate a role for FZD8 in TGF-beta-induced profibrotic signaling and imply that WNT-5B may be the ligand for …

9

Noncanonical WNT-5B signaling induces inflammatory responses in human lung fibroblasts.

van Dijk EM, Menzen MH, Spanjer AI, Middag LD, Brandsma CA, Gosens R. van Dijk EM, et al. Among authors: gosens r. Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1166-76. doi: 10.1152/ajplung.00226.2015. Epub 2016 Apr 1. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27036869 Free article.

10

Elastase-Induced Parenchymal Disruption and Airway Hyper Responsiveness in Mouse Precision Cut Lung Slices: Toward an Ex vivo COPD Model.

Van Dijk EM, Culha S, Menzen MH, Bidan CM, Gosens R. Van Dijk EM, et al. Among authors: gosens r. Front Physiol. 2017 Jan 4;7:657. doi: 10.3389/fphys.2016.00657. eCollection 2016. Front Physiol. 2017. PMID: 28101062 Free PMC article.

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