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Page 1
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.
Jennings D, Huntwork-Rodriguez S, Henry AG, Sasaki JC, Meisner R, Diaz D, Solanoy H, Wang X, Negrou E, Bondar VV, Ghosh R, Maloney MT, Propson NE, Zhu Y, Maciuca RD, Harris L, Kay A, LeWitt P, King TA, Kern D, Ellenbogen A, Goodman I, Siderowf A, Aldred J, Omidvar O, Masoud ST, Davis SS, Arguello A, Estrada AA, de Vicente J, Sweeney ZK, Astarita G, Borin MT, Wong BK, Wong H, Nguyen H, Scearce-Levie K, Ho C, Troyer MD. Jennings D, et al. Among authors: huntwork rodriguez s. Sci Transl Med. 2022 Jun 8;14(648):eabj2658. doi: 10.1126/scitranslmed.abj2658. Epub 2022 Jun 8. Sci Transl Med. 2022. PMID: 35675433
Association of caffeine and related analytes with resistance to Parkinson disease among LRRK2 mutation carriers: A metabolomic study.
Crotty GF, Maciuca R, Macklin EA, Wang J, Montalban M, Davis SS, Alkabsh JI, Bakshi R, Chen X, Ascherio A, Astarita G, Huntwork-Rodriguez S, Schwarzschild MA. Crotty GF, et al. Among authors: huntwork rodriguez s. Neurology. 2020 Dec 15;95(24):e3428-e3437. doi: 10.1212/WNL.0000000000010863. Epub 2020 Sep 30. Neurology. 2020. PMID: 32999056 Free PMC article.
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10.
Wang X, Negrou E, Maloney MT, Bondar VV, Andrews SV, Montalban M, Llapashtica C, Maciuca R, Nguyen H, Solanoy H, Arguello A, Przybyla L, Moerke NJ, Huntwork-Rodriguez S, Henry AG. Wang X, et al. Among authors: huntwork rodriguez s. Sci Rep. 2021 Jun 18;11(1):12900. doi: 10.1038/s41598-021-91943-4. Sci Rep. 2021. PMID: 34145320 Free PMC article.
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.
Jennings D, Huntwork-Rodriguez S, Vissers MFJM, Daryani VM, Diaz D, Goo MS, Chen JJ, Maciuca R, Fraser K, Mabrouk OS, van de Wetering de Rooij J, Heuberger JAAC, Groeneveld GJ, Borin MT, Cruz-Herranz A, Graham D, Scearce-Levie K, De Vicente J, Henry AG, Chin P, Ho C, Troyer MD. Jennings D, et al. Among authors: huntwork rodriguez s. Mov Disord. 2023 Mar;38(3):386-398. doi: 10.1002/mds.29297. Epub 2023 Feb 18. Mov Disord. 2023. PMID: 36807624 Clinical Trial.
A leucine-rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls.
Vissers MFJM, Troyer MD, Thijssen E, Pereira DR, Heuberger JAAC, Groeneveld GJ, Huntwork-Rodriguez S. Vissers MFJM, et al. Among authors: huntwork rodriguez s. Clin Transl Sci. 2023 Aug;16(8):1408-1420. doi: 10.1111/cts.13541. Epub 2023 May 15. Clin Transl Sci. 2023. PMID: 37177855 Free PMC article.
Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.
Larhammar M, Huntwork-Rodriguez S, Jiang Z, Solanoy H, Sengupta Ghosh A, Wang B, Kaminker JS, Huang K, Eastham-Anderson J, Siu M, Modrusan Z, Farley MM, Tessier-Lavigne M, Lewcock JW, Watkins TA. Larhammar M, et al. Among authors: huntwork rodriguez s. Elife. 2017 Apr 25;6:e20725. doi: 10.7554/eLife.20725. Elife. 2017. PMID: 28440222 Free PMC article.
Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase.
Olsen O, Kallop DY, McLaughlin T, Huntwork-Rodriguez S, Wu Z, Duggan CD, Simon DJ, Lu Y, Easley-Neal C, Takeda K, Hass PE, Jaworski A, O'Leary DD, Weimer RM, Tessier-Lavigne M. Olsen O, et al. Among authors: huntwork rodriguez s. J Neurosci. 2014 May 7;34(19):6438-47. doi: 10.1523/JNEUROSCI.3522-13.2014. J Neurosci. 2014. PMID: 24806670 Free PMC article.
13 results