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Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro.
Klose J, Li L, Pahl M, Bendt F, Hübenthal U, Jüngst C, Petzsch P, Schauss A, Köhrer K, Leung PC, Wang CC, Koch K, Tigges J, Fan X, Fritsche E. Klose J, et al. Among authors: fritsche e. Cell Biol Toxicol. 2023 Feb;39(1):319-343. doi: 10.1007/s10565-022-09730-4. Epub 2022 Jun 15. Cell Biol Toxicol. 2023. PMID: 35701726 Free PMC article.
Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation.
Fritsche E, Schäfer C, Calles C, Bernsmann T, Bernshausen T, Wurm M, Hübenthal U, Cline JE, Hajimiragha H, Schroeder P, Klotz LO, Rannug A, Fürst P, Hanenberg H, Abel J, Krutmann J. Fritsche E, et al. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8851-6. doi: 10.1073/pnas.0701764104. Epub 2007 May 14. Proc Natl Acad Sci U S A. 2007. PMID: 17502624 Free PMC article.
Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I).
Götz C, Pfeiffer R, Tigges J, Blatz V, Jäckh C, Freytag EM, Fabian E, Landsiedel R, Merk HF, Krutmann J, Edwards RJ, Pease C, Goebel C, Hewitt N, Fritsche E. Götz C, et al. Among authors: fritsche e. Exp Dermatol. 2012 May;21(5):358-63. doi: 10.1111/j.1600-0625.2012.01486.x. Exp Dermatol. 2012. PMID: 22509833
Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes.
Götz C, Pfeiffer R, Tigges J, Ruwiedel K, Hübenthal U, Merk HF, Krutmann J, Edwards RJ, Abel J, Pease C, Goebel C, Hewitt N, Fritsche E. Götz C, et al. Among authors: fritsche e. Exp Dermatol. 2012 May;21(5):364-9. doi: 10.1111/j.1600-0625.2012.01478.x. Exp Dermatol. 2012. PMID: 22509834
Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression.
Tigges J, Weighardt H, Wolff S, Götz C, Förster I, Kohne Z, Huebenthal U, Merk HF, Abel J, Haarmann-Stemmann T, Krutmann J, Fritsche E. Tigges J, et al. Among authors: fritsche e. J Invest Dermatol. 2013 Jan;133(1):87-96. doi: 10.1038/jid.2012.259. Epub 2012 Sep 6. J Invest Dermatol. 2013. PMID: 22951721 Free article.
Evidence for a novel anti-apoptotic pathway in human keratinocytes involving the aryl hydrocarbon receptor, E2F1, and checkpoint kinase 1.
Frauenstein K, Sydlik U, Tigges J, Majora M, Wiek C, Hanenberg H, Abel J, Esser C, Fritsche E, Krutmann J, Haarmann-Stemmann T. Frauenstein K, et al. Among authors: fritsche e. Cell Death Differ. 2013 Oct;20(10):1425-34. doi: 10.1038/cdd.2013.102. Epub 2013 Aug 2. Cell Death Differ. 2013. PMID: 23912710 Free PMC article.
The new aryl hydrocarbon receptor antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one protects against UVB-induced signal transduction.
Tigges J, Haarmann-Stemmann T, Vogel CFA, Grindel A, Hübenthal U, Brenden H, Grether-Beck S, Vielhaber G, Johncock W, Krutmann J, Fritsche E. Tigges J, et al. Among authors: fritsche e. J Invest Dermatol. 2014 Feb;134(2):556-559. doi: 10.1038/jid.2013.362. Epub 2013 Aug 30. J Invest Dermatol. 2014. PMID: 23995519 Free PMC article. No abstract available.
The hallmarks of fibroblast ageing.
Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F. Tigges J, et al. Among authors: fritsche e. Mech Ageing Dev. 2014 Jun;138:26-44. doi: 10.1016/j.mad.2014.03.004. Epub 2014 Mar 29. Mech Ageing Dev. 2014. PMID: 24686308 Review.
247 results