Denko N - Search Results

1

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.

Viswanathan V, Cao H, Saiki J, Jiang D, Mattingly A, Nambiar D, Bloomstein J, Li Y, Jiang S, Chamoli M, Sirjani D, Kaplan M, Holsinger FC, Liang R, Von Eyben R, Jiang H, Guan L, Lagory E, Feng Z, Nolan G, Ye J, Denko N, Knox S, Rosen DM, Le QT. Viswanathan V, et al. Among authors: denko n. PNAS Nexus. 2022 Jun 9;1(2):pgac056. doi: 10.1093/pnasnexus/pgac056. eCollection 2022 May. PNAS Nexus. 2022. PMID: 35707206 Free PMC article.

2

Candidate genes for the hypoxic tumor phenotype.

Koong AC, Denko NC, Hudson KM, Schindler C, Swiersz L, Koch C, Evans S, Ibrahim H, Le QT, Terris DJ, Giaccia AJ. Koong AC, et al. Among authors: denko nc. Cancer Res. 2000 Feb 15;60(4):883-7. Cancer Res. 2000. PMID: 10706099

3

Hypoxic gene expression and metastasis.

Le QT, Denko NC, Giaccia AJ. Le QT, et al. Cancer Metastasis Rev. 2004 Aug-Dec;23(3-4):293-310. doi: 10.1023/B:CANC.0000031768.89246.d7. Cancer Metastasis Rev. 2004. PMID: 15197330 Review.

4

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. Romero-Ramirez L, et al. Cancer Res. 2004 Sep 1;64(17):5943-7. doi: 10.1158/0008-5472.CAN-04-1606. Cancer Res. 2004. PMID: 15342372

5

Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth.

Spiotto MT, Banh A, Papandreou I, Cao H, Galvez MG, Gurtner GC, Denko NC, Le QT, Koong AC. Spiotto MT, et al. Cancer Res. 2010 Jan 1;70(1):78-88. doi: 10.1158/0008-5472.CAN-09-2747. Epub 2009 Dec 22. Cancer Res. 2010. PMID: 20028872 Free PMC article.

6

The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.

Courter D, Cao H, Kwok S, Kong C, Banh A, Kuo P, Bouley DM, Vice C, Brustugun OT, Denko NC, Koong AC, Giaccia A, Le QT. Courter D, et al. PLoS One. 2010 Mar 10;5(3):e9633. doi: 10.1371/journal.pone.0009633. PLoS One. 2010. PMID: 20224789 Free PMC article.

7

Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.

Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC. Jiang D, et al. Mol Cancer Ther. 2016 Sep;15(9):2055-65. doi: 10.1158/1535-7163.MCT-15-1023. Epub 2016 Jun 15. Mol Cancer Ther. 2016. PMID: 27307600 Free PMC article.

8

A Multimodal Data Analysis Approach for Targeted Drug Discovery Involving Topological Data Analysis (TDA).

Alagappan M, Jiang D, Denko N, Koong AC. Alagappan M, et al. Among authors: denko n. Adv Exp Med Biol. 2016;899:253-68. doi: 10.1007/978-3-319-26666-4_15. Adv Exp Med Biol. 2016. PMID: 27325272 Free PMC article.

9

Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours.

Golias T, Papandreou I, Sun R, Kumar B, Brown NV, Swanson BJ, Pai R, Jaitin D, Le QT, Teknos TN, Denko NC. Golias T, et al. Among authors: denko nc. Sci Rep. 2016 Aug 8;6:31146. doi: 10.1038/srep31146. Sci Rep. 2016. PMID: 27498883 Free PMC article.

10

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response.

Jiang D, Lynch C, Medeiros BC, Liedtke M, Bam R, Tam AB, Yang Z, Alagappan M, Abidi P, Le QT, Giaccia AJ, Denko NC, Niwa M, Koong AC. Jiang D, et al. Sci Rep. 2016 Sep 16;6:33353. doi: 10.1038/srep33353. Sci Rep. 2016. PMID: 27634301 Free PMC article.

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