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Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone.
Lin SY, Tien YW, Ke YY, Chang YC, Chang HF, Ou LC, Law PY, Xi JH, Tao PL, Loh HH, Chao YS, Shih C, Chen CT, Yeh SH, Ueng SH. Lin SY, et al. Among authors: chen ct. Bioorg Chem. 2022 Nov;128:105905. doi: 10.1016/j.bioorg.2022.105905. Epub 2022 Jun 2. Bioorg Chem. 2022. PMID: 35710525
Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.
Mahindroo N, Huang CF, Peng YH, Wang CC, Liao CC, Lien TW, Chittimalla SK, Huang WJ, Chai CH, Prakash E, Chen CP, Hsu TA, Peng CH, Lu IL, Lee LH, Chang YW, Chen WC, Chou YC, Chen CT, Goparaju CM, Chen YS, Lan SJ, Yu MC, Chen X, Chao YS, Wu SY, Hsieh HP. Mahindroo N, et al. Among authors: chen ct, chen wc, chen cp, chen ys, chen x. J Med Chem. 2005 Dec 29;48(26):8194-208. doi: 10.1021/jm0506930. J Med Chem. 2005. PMID: 16366601
2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.
Tsu H, Chen X, Chen CT, Lee SJ, Chang CN, Kao KH, Coumar MS, Yeh YT, Chien CH, Wang HS, Lin KT, Chang YY, Wu SH, Chen YS, Lu IL, Wu SY, Tsai TY, Chen WC, Hsieh HP, Chao YS, Jiaang WT. Tsu H, et al. Among authors: chen ct, chen wc, chen x, chen ys. J Med Chem. 2006 Jan 12;49(1):373-80. doi: 10.1021/jm0507781. J Med Chem. 2006. PMID: 16392822
Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.
Lu IL, Huang CF, Peng YH, Lin YT, Hsieh HP, Chen CT, Lien TW, Lee HJ, Mahindroo N, Prakash E, Yueh A, Chen HY, Goparaju CM, Chen X, Liao CC, Chao YS, Hsu JT, Wu SY. Lu IL, et al. Among authors: chen ct, chen hy, chen x. J Med Chem. 2006 May 4;49(9):2703-12. doi: 10.1021/jm051129s. J Med Chem. 2006. PMID: 16640330
Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: application to a pharmacokinetic study.
Chang YW, Chen WC, Lin KT, Chang L, Yao HT, Hsieh HP, Lan SJ, Chen CT, Chao YS, Yeh TK. Chang YW, et al. Among authors: chen ct, chen wc. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Feb 1;846(1-2):162-8. doi: 10.1016/j.jchromb.2006.08.040. Epub 2006 Sep 26. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17005456
3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.
Coumar MS, Chang CN, Chen CT, Chen X, Chien CH, Tsai TY, Cheng JH, Wu HY, Han CH, Wu SH, Huang YW, Hsu T, Hsu LJ, Chao YS, Hsieh HP, Jiaang WT. Coumar MS, et al. Among authors: chen ct, chen x. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1274-9. doi: 10.1016/j.bmcl.2006.12.019. Epub 2006 Dec 12. Bioorg Med Chem Lett. 2007. PMID: 17194587
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.
Tsai TY, Hsu T, Chen CT, Cheng JH, Yeh TK, Chen X, Huang CY, Chang CN, Yeh KC, Hsieh SH, Chien CH, Chang YW, Huang CH, Huang YW, Huang CL, Wu SH, Wang MH, Lu CT, Chao YS, Jiaang WT. Tsai TY, et al. Among authors: chen ct, chen x. Bioorg Med Chem. 2009 Mar 15;17(6):2388-99. doi: 10.1016/j.bmc.2009.02.020. Epub 2009 Feb 20. Bioorg Med Chem. 2009. PMID: 19261480
1,726 results