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Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule.
Grinkevich VV, Vema A, Fawkner K, Issaeva N, Andreotti V, Dickinson ER, Hedström E, Spinnler C, Inga A, Larsson LG, Karlén A, Wilhelm M, Barran PE, Okorokov AL, Selivanova G, Zawacka-Pankau JE. Grinkevich VV, et al. Among authors: larsson lg. Front Mol Biosci. 2022 Jun 1;9:823195. doi: 10.3389/fmolb.2022.823195. eCollection 2022. Front Mol Biosci. 2022. PMID: 35720128 Free PMC article.
MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner.
Castell A, Yan Q, Fawkner K, Bazzar W, Zhang F, Wickström M, Alzrigat M, Franco M, Krona C, Cameron DP, Dyberg C, Olsen TK, Verschut V, Schmidt L, Lim SY, Mahmoud L, Hydbring P, Lehmann S, Baranello L, Nelander S, Johnsen JI, Larsson LG. Castell A, et al. Among authors: larsson lg. Cancer Res Commun. 2022 Mar 31;2(3):182-201. doi: 10.1158/2767-9764.CRC-21-0019. eCollection 2022 Mar. Cancer Res Commun. 2022. PMID: 36874405 Free PMC article.
Methods to study MYC-regulated cellular senescence.
Tabor V, Bocci M, Larsson LG. Tabor V, et al. Among authors: larsson lg. Methods Mol Biol. 2013;1012:99-116. doi: 10.1007/978-1-62703-429-6_8. Methods Mol Biol. 2013. PMID: 24006061
CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.
Cepeda D, Ng HF, Sharifi HR, Mahmoudi S, Cerrato VS, Fredlund E, Magnusson K, Nilsson H, Malyukova A, Rantala J, Klevebring D, Viñals F, Bhaskaran N, Zakaria SM, Rahmanto AS, Grotegut S, Nielsen ML, Szigyarto CA, Sun D, Lerner M, Navani S, Widschwendter M, Uhlén M, Jirström K, Pontén F, Wohlschlegel J, Grandér D, Spruck C, Larsson LG, Sangfelt O. Cepeda D, et al. Among authors: larsson lg. EMBO Mol Med. 2013 Jul;5(7):1067-86. doi: 10.1002/emmm.201202341. Epub 2013 Jun 14. EMBO Mol Med. 2013. PMID: 23776131 Free PMC article.
218 results