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CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.
Antony PA, Piccirillo CA, Akpinarli A, Finkelstein SE, Speiss PJ, Surman DR, Palmer DC, Chan CC, Klebanoff CA, Overwijk WW, Rosenberg SA, Restifo NP. Antony PA, et al. Among authors: overwijk ww. J Immunol. 2005 Mar 1;174(5):2591-601. doi: 10.4049/jimmunol.174.5.2591. J Immunol. 2005. PMID: 15728465 Free PMC article.
T helper 17 cells promote cytotoxic T cell activation in tumor immunity.
Martin-Orozco N, Muranski P, Chung Y, Yang XO, Yamazaki T, Lu S, Hwu P, Restifo NP, Overwijk WW, Dong C. Martin-Orozco N, et al. Among authors: overwijk ww. Immunity. 2009 Nov 20;31(5):787-98. doi: 10.1016/j.immuni.2009.09.014. Epub 2009 Oct 29. Immunity. 2009. PMID: 19879162 Free PMC article.
Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model.
Kong LY, Gelbard A, Wei J, Reina-Ortiz C, Wang Y, Yang EC, Hailemichael Y, Fokt I, Jayakumar A, Qiao W, Fuller GN, Overwijk WW, Priebe W, Heimberger AB. Kong LY, et al. Among authors: overwijk ww. Clin Cancer Res. 2010 May 1;16(9):2550-61. doi: 10.1158/1078-0432.CCR-10-0279. Epub 2010 Apr 13. Clin Cancer Res. 2010. PMID: 20388845 Free PMC article.
116 results