El-Khamisy SF - Search Results

1

CORM-3 induces DNA damage through Ru(II) binding to DNA.

Lyon RF, Southam HM, Trevitt CR, Liao C, El-Khamisy SF, Poole RK, Williamson MP. Lyon RF, et al. Biochem J. 2022 Jul 15;479(13):1429-1439. doi: 10.1042/BCJ20220254. Biochem J. 2022. PMID: 35726678 Free PMC article.

2

Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.

Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE, El-Khamisy SF. Meisenberg C, et al. Nucleic Acids Res. 2017 Feb 17;45(3):1159-1176. doi: 10.1093/nar/gkw1026. Nucleic Acids Res. 2017. PMID: 28180300 Free PMC article.

3

C9orf72 expansion disrupts ATM-mediated chromosomal break repair.

Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Elsayed W, Lukashchuk V, Chiang SC, Ray S, Mulcahy PJ, Jurga M, Tsagakis I, Iannitti T, Chandran J, Coldicott I, De Vos KJ, Hassan MK, Higginbottom A, Shaw PJ, Hautbergue GM, Azzouz M, El-Khamisy SF. Walker C, et al. Nat Neurosci. 2017 Sep;20(9):1225-1235. doi: 10.1038/nn.4604. Epub 2017 Jul 17. Nat Neurosci. 2017. PMID: 28714954 Free PMC article.

4

Role of Protein Linked DNA Breaks in Cancer.

Allam WR, Ashour ME, Waly AA, El-Khamisy S. Allam WR, et al. Adv Exp Med Biol. 2017;1007:41-58. doi: 10.1007/978-3-319-60733-7_3. Adv Exp Med Biol. 2017. PMID: 28840551

5

UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.

Liao C, Beveridge R, Hudson JJR, Parker JD, Chiang SC, Ray S, Ashour ME, Sudbery I, Dickman MJ, El-Khamisy SF. Liao C, et al. Cell Rep. 2018 Jun 12;23(11):3352-3365. doi: 10.1016/j.celrep.2018.05.033. Cell Rep. 2018. PMID: 29898404 Free PMC article.

6

A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3.

Southam HM, Smith TW, Lyon RL, Liao C, Trevitt CR, Middlemiss LA, Cox FL, Chapman JA, El-Khamisy SF, Hippler M, Williamson MP, Henderson PJF, Poole RK. Southam HM, et al. Redox Biol. 2018 Sep;18:114-123. doi: 10.1016/j.redox.2018.06.008. Epub 2018 Jun 30. Redox Biol. 2018. PMID: 30007887 Free PMC article.

7

Defective repair of topoisomerase I induced chromosomal damage in Huntington's disease.

Palminha NM, Dos Santos Souza C, Griffin J, Liao C, Ferraiuolo L, El-Khamisy SF. Palminha NM, et al. Cell Mol Life Sci. 2022 Feb 28;79(3):160. doi: 10.1007/s00018-022-04204-6. Cell Mol Life Sci. 2022. PMID: 35224690 Free PMC article.

8

A mechanism for oxidative damage repair at gene regulatory elements.

Ray S, Abugable AA, Parker J, Liversidge K, Palminha NM, Liao C, Acosta-Martin AE, Souza CDS, Jurga M, Sudbery I, El-Khamisy SF. Ray S, et al. Nature. 2022 Sep;609(7929):1038-1047. doi: 10.1038/s41586-022-05217-8. Epub 2022 Sep 28. Nature. 2022. PMID: 36171374 Free article.

9

High Glucose Increases DNA Damage and Elevates the Expression of Multiple DDR Genes.

Rahmoon MA, Elghaish RA, Ibrahim AA, Alaswad Z, Gad MZ, El-Khamisy SF, Elserafy M. Rahmoon MA, et al. Among authors: el khamisy sf. Genes (Basel). 2023 Jan 5;14(1):144. doi: 10.3390/genes14010144. Genes (Basel). 2023. PMID: 36672885 Free PMC article.

10

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.

Alagoz M, Wells OS, El-Khamisy SF. Alagoz M, et al. Nucleic Acids Res. 2014 Mar;42(5):3089-103. doi: 10.1093/nar/gkt1260. Epub 2013 Dec 13. Nucleic Acids Res. 2014. PMID: 24335147 Free PMC article.

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