Scarfe G - Search Results

1

Considerations for Human ADME Strategy and Design Paradigm Shift(s) - An Industry White Paper.

Young GC, Spracklin DK, James AD, Hvenegaard MG, Scarfe G, Wagner DS, Georgi K, Schieferstein H, Bjornsdottir I, van Groen B, Romeo AA, Cassidy KC, Da-Violante G, Bister B, Blech S, Lyer R, Schulz SI, Cuyckens F, Moliner P. Young GC, et al. Among authors: scarfe g. Clin Pharmacol Ther. 2023 Apr;113(4):775-781. doi: 10.1002/cpt.2691. Epub 2022 Sep 2. Clin Pharmacol Ther. 2023. PMID: 35733280

2

Physiologically Based Pharmacokinetic Modeling for Olaparib Dosing Recommendations: Bridging Formulations, Drug Interactions, and Patient Populations.

Pilla Reddy V, Bui K, Scarfe G, Zhou D, Learoyd M. Pilla Reddy V, et al. Among authors: scarfe g. Clin Pharmacol Ther. 2019 Jan;105(1):229-241. doi: 10.1002/cpt.1103. Epub 2018 Aug 9. Clin Pharmacol Ther. 2019. PMID: 29717476 Free PMC article.

3

In vitro evaluation of the inhibition and induction potential of olaparib, a potent poly(ADP-ribose) polymerase inhibitor, on cytochrome P450.

McCormick A, Swaisland H, Reddy VP, Learoyd M, Scarfe G. McCormick A, et al. Among authors: scarfe g. Xenobiotica. 2018 Jun;48(6):555-564. doi: 10.1080/00498254.2017.1346332. Epub 2017 Jul 25. Xenobiotica. 2018. PMID: 28657402

4

Clinical evaluation of the potential drug-drug interactions of savolitinib: Interaction with rifampicin, itraconazole, famotidine or midazolam.

Ren S, Vishwanathan K, Cantarini M, Frewer P, Hara I, Scarfe G, Burke W, Schalkwijk S, Li Y, Han D, Goldwater R. Ren S, et al. Among authors: scarfe g. Br J Clin Pharmacol. 2022 Feb;88(2):655-668. doi: 10.1111/bcp.14994. Epub 2021 Aug 21. Br J Clin Pharmacol. 2022. PMID: 34322894 Free PMC article.

5

A Phase I Study to Investigate the Absorption, Pharmacokinetics, and Excretion of [(14)C]Prucalopride After a Single Oral Dose in Healthy Volunteers.

Flach S, Scarfe G, Dragone J, Ding J, Seymour M, Pennick M, Pankratz T, Troy S, Getsy J. Flach S, et al. Among authors: scarfe g. Clin Ther. 2016 Sep;38(9):2106-15. doi: 10.1016/j.clinthera.2016.08.003. Epub 2016 Sep 7. Clin Ther. 2016. PMID: 27614912 Free article. Clinical Trial.

6

Phase I study of orally administered ¹⁴Carbon-isotope labelled-vistusertib (AZD2014), a dual TORC1/2 kinase inhibitor, to assess the absorption, metabolism, excretion, and pharmacokinetics in patients with advanced solid malignancies.

MacDonald A, Scarfe G, Magirr D, Sarvotham T, Charlton J, Brugger W, Dean E. MacDonald A, et al. Among authors: scarfe g. Cancer Chemother Pharmacol. 2019 Apr;83(4):787-795. doi: 10.1007/s00280-019-03781-x. Epub 2019 Feb 13. Cancer Chemother Pharmacol. 2019. PMID: 30758651 Clinical Trial.

7

CYP-Mediated Sulfoximine Deimination of AZD6738.

Jones BC, Markandu R, Gu C, Scarfe G. Jones BC, et al. Among authors: scarfe g. Drug Metab Dispos. 2017 Nov;45(11):1133-1138. doi: 10.1124/dmd.117.077776. Epub 2017 Aug 23. Drug Metab Dispos. 2017. PMID: 28835442

8

Pharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase I clinical trial using a microtracer and accelerator mass spectrometry-based approach.

Flach S, Croft M, Ding J, Budhram R, Pankratz T, Pennick M, Scarfe G, Troy S, Getsy J. Flach S, et al. Among authors: scarfe g. Drug Des Devel Ther. 2016 Sep 27;10:3125-3132. doi: 10.2147/DDDT.S107843. eCollection 2016. Drug Des Devel Ther. 2016. PMID: 27729771 Free PMC article. Clinical Trial.

9

The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture.

Pichard-Garcia L, Weaver RJ, Eckett N, Scarfe G, Fabre JM, Lucas C, Maurel P. Pichard-Garcia L, et al. Among authors: scarfe g. Drug Metab Dispos. 2004 Jan;32(1):80-8. doi: 10.1124/dmd.32.1.80. Drug Metab Dispos. 2004. PMID: 14709624

10

19F-NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4-trifluoromethylaniline in rat: a urinary excretion balance study without the use of radiolabelling.

Scarfe GB, Wright B, Clayton E, Taylor S, Wilson ID, Lindon JC, Nicholson JK. Scarfe GB, et al. Xenobiotica. 1998 Apr;28(4):373-88. doi: 10.1080/004982598239489. Xenobiotica. 1998. PMID: 9604301

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