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Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.
Golebiewska A, Hau AC, Oudin A, Stieber D, Yabo YA, Baus V, Barthelemy V, Klein E, Bougnaud S, Keunen O, Wantz M, Michelucci A, Neirinckx V, Muller A, Kaoma T, Nazarov PV, Azuaje F, De Falco A, Flies B, Richart L, Poovathingal S, Arns T, Grzyb K, Mock A, Herold-Mende C, Steino A, Brown D, May P, Miletic H, Malta TM, Noushmehr H, Kwon YJ, Jahn W, Klink B, Tanner G, Stead LF, Mittelbronn M, Skupin A, Hertel F, Bjerkvig R, Niclou SP. Golebiewska A, et al. Among authors: kwon yj. Acta Neuropathol. 2020 Dec;140(6):919-949. doi: 10.1007/s00401-020-02226-7. Epub 2020 Oct 3. Acta Neuropathol. 2020. PMID: 33009951 Free PMC article.
Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid.
Kim H, El-Khoury V, Schulte N, Zhan T, Betge J, Cousin L, Felli E, Pessaux P, Ogier A, Opitz O, Ku B, Ebert MP, Kwon YJ. Kim H, et al. Among authors: kwon yj. Cancer Biol Ther. 2022 Dec 31;23(1):96-102. doi: 10.1080/15384047.2021.2021042. Cancer Biol Ther. 2022. PMID: 35193475 Free PMC article.
High-content phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification.
Vuidel A, Cousin L, Weykopf B, Haupt S, Hanifehlou Z, Wiest-Daesslé N, Segschneider M, Lee J, Kwon YJ, Peitz M, Ogier A, Brino L, Brüstle O, Sommer P, Wilbertz JH. Vuidel A, et al. Among authors: kwon yj. Stem Cell Reports. 2022 Oct 11;17(10):2349-2364. doi: 10.1016/j.stemcr.2022.09.001. Epub 2022 Sep 29. Stem Cell Reports. 2022. PMID: 36179692 Free PMC article.
Prediction of TKI response in EGFR-mutant lung cancer patients-derived organoids using malignant pleural effusion.
Lee SH, Kim K, Lee E, Lee K, Ahn KH, Park H, Kim Y, Shin S, Jeon SY, Hwang Y, Ahn DH, Kwon YJ, Moon SW, Moon MH, Kim KS, Hyun K, Kim TJ, Sung YE, Choi JY, Park CK, Kim SW, Yeo CD, Sohn HJ, Hyun YS, Kim TG, Ku B, Lim JU, Kim SJ. Lee SH, et al. Among authors: kwon yj. NPJ Precis Oncol. 2024 May 21;8(1):111. doi: 10.1038/s41698-024-00609-7. NPJ Precis Oncol. 2024. PMID: 38773241 Free PMC article.
Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy.
Lee HW, Lee JI, Lee SJ, Cho HJ, Song HJ, Jeong DE, Seo YJ, Shin S, Joung JG, Kwon YJ, Choi YL, Park WY, Lee HM, Seol HJ, Shim YM, Joo KM, Nam DH. Lee HW, et al. Among authors: kwon yj. Clin Cancer Res. 2015 Mar 1;21(5):1172-82. doi: 10.1158/1078-0432.CCR-14-1589. Epub 2014 Dec 30. Clin Cancer Res. 2015. PMID: 25549722
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy.
Lee JK, Liu Z, Sa JK, Shin S, Wang J, Bordyuh M, Cho HJ, Elliott O, Chu T, Choi SW, Rosenbloom DIS, Lee IH, Shin YJ, Kang HJ, Kim D, Kim SY, Sim MH, Kim J, Lee T, Seo YJ, Shin H, Lee M, Kim SH, Kwon YJ, Oh JW, Song M, Kim M, Kong DS, Choi JW, Seol HJ, Lee JI, Kim ST, Park JO, Kim KM, Song SY, Lee JW, Kim HC, Lee JE, Choi MG, Seo SW, Shim YM, Zo JI, Jeong BC, Yoon Y, Ryu GH, Kim NKD, Bae JS, Park WY, Lee J, Verhaak RGW, Iavarone A, Lee J, Rabadan R, Nam DH. Lee JK, et al. Among authors: kwon yj. Nat Genet. 2018 Oct;50(10):1399-1411. doi: 10.1038/s41588-018-0209-6. Epub 2018 Sep 27. Nat Genet. 2018. PMID: 30262818 Free PMC article.
1,018 results