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PI3K-α/mTOR/BRD4 inhibitor alone or in combination with other anti-virals blocks replication of SARS-CoV-2 and its variants of concern including Delta and Omicron.
Acharya A, Pathania AS, Pandey K, Thurman M, Vann KR, Kutateladze TG, Challagundala KB, Durden DL, Byrareddy SN. Acharya A, et al. Among authors: kutateladze tg. Clin Transl Med. 2022 Apr;12(4):e806. doi: 10.1002/ctm2.806. Clin Transl Med. 2022. PMID: 35390226 Free PMC article. No abstract available.
Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
Vann KR, Acharya A, Jang SM, Lachance C, Zandian M, Holt TA, Smith AL, Pandey K, Durden DL, El-Gamal D, Côté J, Byrareddy SN, Kutateladze TG. Vann KR, et al. Among authors: kutateladze tg. Structure. 2022 Sep 1;30(9):1224-1232.e5. doi: 10.1016/j.str.2022.05.020. Epub 2022 Jun 17. Structure. 2022. PMID: 35716662 Free PMC article.
195 results