Lee H - Search Results

1

A population PK-PD model of YH4808, a novel P-CAB, and intragastric pH that incorporated negative feedback by increased intragastric pH onto the systemic exposure to YH4808.

Chung TK, Lee HA, Lee KR, Jang SB, Yu KS, Lee H. Chung TK, et al. Among authors: lee kr, lee ha, lee h. CPT Pharmacometrics Syst Pharmacol. 2022 Sep;11(9):1223-1233. doi: 10.1002/psp4.12839. Epub 2022 Jul 9. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35748058 Free PMC article.

2

A physiologically-based pharmacokinetic model adequately predicted the human pharmacokinetic profiles of YH4808, a novel K⁺-competitive acid blocker.

Lee HA, Lee KR, Jang SB, Chung SY, Yu KS, Lee H. Lee HA, et al. Among authors: lee kr, lee h. Eur J Pharm Sci. 2019 Mar 15;130:1-10. doi: 10.1016/j.ejps.2019.01.009. Epub 2019 Jan 11. Eur J Pharm Sci. 2019. PMID: 30641142 Clinical Trial.

3

A population pharmacokinetic-pharmacodynamic model of YH12852, a highly selective 5-hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation.

Kim S, Lee HA, Jang SB, Lee H. Kim S, et al. Among authors: lee ha, lee h. CPT Pharmacometrics Syst Pharmacol. 2021 Aug;10(8):902-913. doi: 10.1002/psp4.12664. Epub 2021 Jul 3. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34085769 Free PMC article. Clinical Trial.

4

A target-mediated drug disposition population pharmacokinetic model of GC1118, a novel anti-EGFR antibody, in patients with solid tumors.

Chung TK, Lee HA, Park SI, Oh DY, Lee KW, Kim JW, Kim JH, Woo A, Lee SJ, Bang YJ, Lee H. Chung TK, et al. Among authors: lee sj, lee ha, lee h, lee kw. Clin Transl Sci. 2021 May;14(3):990-1001. doi: 10.1111/cts.12963. Epub 2021 Jan 25. Clin Transl Sci. 2021. PMID: 33382918 Free PMC article. Clinical Trial.

5

Physiologically Based Pharmacokinetic Modeling of Fimasartan, Amlodipine, and Hydrochlorothiazide for the Investigation of Drug-Drug Interaction Potentials.

Rhee SJ, Lee HA, Lee S, Kim E, Jeon I, Song IS, Yu KS. Rhee SJ, et al. Pharm Res. 2018 Oct 15;35(12):236. doi: 10.1007/s11095-018-2511-5. Pharm Res. 2018. PMID: 30324316

6

Development of a Korean-specific virtual population for physiologically based pharmacokinetic modelling and simulation.

Kim Y, Hatley O, Rhee SJ, Yi S, Lee HA, Yoon S, Chung JY, Yu KS, Lee H. Kim Y, et al. Among authors: lee ha, lee h. Biopharm Drug Dispos. 2019 Apr;40(3-4):135-150. doi: 10.1002/bdd.2178. Biopharm Drug Dispos. 2019. PMID: 30921829

7

URC102, a potent and selective inhibitor of hURAT1, reduced serum uric acid in healthy volunteers.

Lee HA, Yu KS, Park SI, Yoon S, Onohara M, Ahn Y, Lee H. Lee HA, et al. Among authors: lee h. Rheumatology (Oxford). 2019 Nov 1;58(11):1976-1984. doi: 10.1093/rheumatology/kez140. Rheumatology (Oxford). 2019. PMID: 31056705 Clinical Trial.

8

Development of a physiologically-based pharmacokinetic model for cyclosporine in Asian children with renal impairment.

Yoon S, Yi S, Rhee SJ, Lee HA, Kim Y, Yu KS, Chung JY. Yoon S, et al. Transl Clin Pharmacol. 2019 Sep;27(3):107-114. doi: 10.12793/tcp.2019.27.3.107. Epub 2019 Sep 30. Transl Clin Pharmacol. 2019. PMID: 32055591 Free PMC article.

9

A Machine Learning-Based Identification of Genes Affecting the Pharmacokinetics of Tacrolimus Using the DMET^TM Plus Platform.

Gim JA, Kwon Y, Lee HA, Lee KR, Kim S, Choi Y, Kim YK, Lee H. Gim JA, et al. Among authors: lee kr, lee ha, lee h. Int J Mol Sci. 2020 Apr 4;21(7):2517. doi: 10.3390/ijms21072517. Int J Mol Sci. 2020. PMID: 32260456 Free PMC article.

10

YH12852, a Potent and Selective Receptor Agonist of 5-hydroxytryptamine, Increased Gastrointestinal Motility in Healthy Volunteers and Patients With Functional Constipation.

Lee HA, Ju Moon S, Yoo H, Kyung Kim M, Bok Jang S, Lee S, Kim S, Lee H. Lee HA, et al. Among authors: lee h, lee s. Clin Transl Sci. 2021 Mar;14(2):625-634. doi: 10.1111/cts.12924. Epub 2020 Nov 30. Clin Transl Sci. 2021. PMID: 33202093 Free PMC article. Clinical Trial.

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