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Page 1
Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke.
Spitzer D, Guérit S, Puetz T, Khel MI, Armbrust M, Dunst M, Macas J, Zinke J, Devraj G, Jia X, Croll F, Sommer K, Filipski K, Freiman TM, Looso M, Günther S, Di Tacchio M, Plate KH, Reiss Y, Liebner S, Harter PN, Devraj K. Spitzer D, et al. Among authors: plate kh. Acta Neuropathol. 2022 Aug;144(2):305-337. doi: 10.1007/s00401-022-02452-1. Epub 2022 Jun 25. Acta Neuropathol. 2022. PMID: 35752654 Free PMC article.
Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling.
Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, Sommer K, Di Tacchio M, Vutukuri R, Beck H, Mittelbronn M, Foerch C, Pfeilschifter W, Liebner S, Peters KG, Plate KH, Reiss Y. Gurnik S, et al. Among authors: plate kh. Acta Neuropathol. 2016 May;131(5):753-73. doi: 10.1007/s00401-016-1551-3. Epub 2016 Mar 1. Acta Neuropathol. 2016. PMID: 26932603 Free PMC article.
Functional morphology of the blood-brain barrier in health and disease.
Liebner S, Dijkhuizen RM, Reiss Y, Plate KH, Agalliu D, Constantin G. Liebner S, et al. Among authors: plate kh. Acta Neuropathol. 2018 Mar;135(3):311-336. doi: 10.1007/s00401-018-1815-1. Epub 2018 Feb 6. Acta Neuropathol. 2018. PMID: 29411111 Free PMC article. Review.
HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis.
Devraj G, Guérit S, Seele J, Spitzer D, Macas J, Khel MI, Heidemann R, Braczynski AK, Ballhorn W, Günther S, Ogunshola OO, Mittelbronn M, Ködel U, Monoranu CM, Plate KH, Hammerschmidt S, Nau R, Devraj K, Kempf VAJ. Devraj G, et al. Among authors: plate kh. Acta Neuropathol. 2020 Aug;140(2):183-208. doi: 10.1007/s00401-020-02174-2. Epub 2020 Jun 11. Acta Neuropathol. 2020. PMID: 32529267 Free PMC article.
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression.
Reis M, Czupalla CJ, Ziegler N, Devraj K, Zinke J, Seidel S, Heck R, Thom S, Macas J, Bockamp E, Fruttiger M, Taketo MM, Dimmeler S, Plate KH, Liebner S. Reis M, et al. Among authors: plate kh. J Exp Med. 2012 Aug 27;209(9):1611-27. doi: 10.1084/jem.20111580. Epub 2012 Aug 20. J Exp Med. 2012. PMID: 22908324 Free PMC article.
Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma.
Scholz A, Harter PN, Cremer S, Yalcin BH, Gurnik S, Yamaji M, Di Tacchio M, Sommer K, Baumgarten P, Bähr O, Steinbach JP, Trojan J, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Braun C, Schittenhelm J, Frueh JT, Ullrich E, Mittelbronn M, Plate KH, Reiss Y. Scholz A, et al. Among authors: plate kh. EMBO Mol Med. 2016 Jan 1;8(1):39-57. doi: 10.15252/emmm.201505505. EMBO Mol Med. 2016. PMID: 26666269 Free PMC article.
Brain invasion in otherwise benign meningiomas does not predict tumor recurrence.
Baumgarten P, Gessler F, Schittenhelm J, Skardelly M, Tews DS, Senft C, Dunst M, Imoehl L, Plate KH, Wagner M, Steinbach JP, Seifert V, Mittelbronn M, Harter PN. Baumgarten P, et al. Among authors: plate kh. Acta Neuropathol. 2016 Sep;132(3):479-81. doi: 10.1007/s00401-016-1598-1. Epub 2016 Jul 27. Acta Neuropathol. 2016. PMID: 27464983 No abstract available.
Lack of H3K27 trimethylation is associated with 1p/19q codeletion in diffuse gliomas.
Filipski K, Braun Y, Zinke J, Roller B, Baumgarten P, Wagner M, Senft C, Zeiner PS, Ronellenfitsch MW, Steinbach JP, Plate KH, Gasparoni G, Mittelbronn M, Capper D, Harter PN. Filipski K, et al. Among authors: plate kh. Acta Neuropathol. 2019 Aug;138(2):331-334. doi: 10.1007/s00401-019-02025-9. Epub 2019 May 7. Acta Neuropathol. 2019. PMID: 31065834 Free PMC article. No abstract available.
Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF.
Di Tacchio M, Macas J, Weissenberger J, Sommer K, Bähr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Büttner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Günther S, Devraj K, Plate KH, Reiss Y. Di Tacchio M, et al. Among authors: plate kh. Cancer Immunol Res. 2019 Dec;7(12):1910-1927. doi: 10.1158/2326-6066.CIR-18-0865. Epub 2019 Oct 9. Cancer Immunol Res. 2019. PMID: 31597643
191 results