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mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis.
Eskandari SK, Allos H, Al Dulaijan BS, Melhem G, Sulkaj I, Alhaddad JB, Saad AJ, Deban C, Chu P, Choi JY, Kollar B, Pomahac B, Riella LV, Berger SP, Sanders JSF, Lieberman J, Li L, Azzi JR. Eskandari SK, et al. Among authors: lieberman j. Front Immunol. 2022 Jun 10;13:899975. doi: 10.3389/fimmu.2022.899975. eCollection 2022. Front Immunol. 2022. PMID: 35757726 Free PMC article.
Granzyme B-induced mitochondrial ROS are required for apoptosis.
Jacquemin G, Margiotta D, Kasahara A, Bassoy EY, Walch M, Thiery J, Lieberman J, Martinvalet D. Jacquemin G, et al. Among authors: lieberman j. Cell Death Differ. 2015 May;22(5):862-74. doi: 10.1038/cdd.2014.180. Epub 2014 Oct 31. Cell Death Differ. 2015. PMID: 25361078 Free PMC article.
Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation.
Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Sula Karreci E, et al. Among authors: lieberman j. JCI Insight. 2017 Nov 2;2(21):e91599. doi: 10.1172/jci.insight.91599. JCI Insight. 2017. PMID: 29093262 Free PMC article.
2,079 results