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Ketamine treatment partly reverses alterations in brain derived- neurotrophic factor, oxidative stress and energy metabolism parameters induced by an animal model of depression.
Réus GZ, Nacif MP, Abelaira HM, Tomaz DB, dos Santos MA, Carlessi AS, Matias BI, da Luz JR, Steckert AV, Jeremias GC, Scaini G, Morais MO, Streck EL, Quevedo J. Réus GZ, et al. Among authors: tomaz db. Curr Neurovasc Res. 2015;12(1):73-84. doi: 10.2174/1567202612666150122122924. Curr Neurovasc Res. 2015. PMID: 25613382
Treatment with tianeptine induces antidepressive-like effects and alters the neurotrophin levels, mitochondrial respiratory chain and cycle Krebs enzymes in the brain of maternally deprived adult rats.
Della FP, Abelaira HM, Réus GZ, Santos MA, Tomaz DB, Antunes AR, Scaini G, Morais MO, Streck EL, Quevedo J. Della FP, et al. Among authors: tomaz db. Metab Brain Dis. 2013 Mar;28(1):93-105. doi: 10.1007/s11011-012-9375-x. Epub 2013 Jan 18. Metab Brain Dis. 2013. PMID: 23325329
MAPK signaling correlates with the antidepressant effects of ketamine.
Réus GZ, Vieira FG, Abelaira HM, Michels M, Tomaz DB, dos Santos MA, Carlessi AS, Neotti MV, Matias BI, Luz JR, Dal-Pizzol F, Quevedo J. Réus GZ, et al. Among authors: tomaz db. J Psychiatr Res. 2014 Aug;55:15-21. doi: 10.1016/j.jpsychires.2014.04.010. Epub 2014 Apr 18. J Psychiatr Res. 2014. PMID: 24819632
Anxious phenotypes plus environmental stressors are related to brain DNA damage and changes in NMDA receptor subunits and glutamate uptake.
Réus GZ, Abaleira HM, Michels M, Tomaz DB, dos Santos MA, Carlessi AS, Matias BI, Leffa DD, Damiani AP, Gomes Vde C, Andrade VM, Dal-Pizzol F, Landeira-Fernadez J, Quevedo J. Réus GZ, et al. Among authors: tomaz db. Mutat Res. 2015 Feb;772:30-7. doi: 10.1016/j.mrfmmm.2014.12.005. Epub 2014 Dec 27. Mutat Res. 2015. PMID: 25772108