Mannan-binding lectin, a serum collectin, suppresses T-cell proliferation via direct interaction with cell surface calreticulin and inhibition of proximal T-cell receptor signaling.
Zhao N, Wu J, Xiong S, Zhang L, Lu X, Chen S, Wu Q, Wang H, Liu Y, Chen Z, Zuo D.
Zhao N, et al.
FASEB J. 2017 Jun;31(6):2405-2417. doi: 10.1096/fj.201601200RR. Epub 2017 Feb 16.
FASEB J. 2017.
PMID: 28209773
Furthermore, MBL efficiently inhibited activation and proliferation of autoreactive T cells derived from patients with silicosis, indicating that MBL serves as a negative feedback control of the T-cell responses.-Zhao, N., Wu, J., Xiong, S., Zhang, L., Lu, X., Chen, …
Furthermore, MBL efficiently inhibited activation and proliferation of autoreactive T cells derived from patients with silicosis, indicating …