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ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance.
Jang SC, Economides KD, Moniz RJ, Sia CL, Lewis N, McCoy C, Zi T, Zhang K, Harrison RA, Lim J, Dey J, Grenley M, Kirwin K, Ross NL, Bourdeau R, Villiger-Oberbek A, Estes S, Xu K, Sanchez-Salazar J, Dooley K, Dahlberg WK, Williams DE, Sathyanarayanan S. Jang SC, et al. Commun Biol. 2021 Apr 22;4(1):497. doi: 10.1038/s42003-021-02004-5. Commun Biol. 2021. PMID: 33888863 Free PMC article.
Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity.
Kamerkar S, Leng C, Burenkova O, Jang SC, McCoy C, Zhang K, Dooley K, Kasera S, Zi T, Sisó S, Dahlberg W, Sia CL, Patel S, Schmidt K, Economides K, Soos T, Burzyn D, Sathyanarayanan S. Kamerkar S, et al. Among authors: jang sc. Sci Adv. 2022 Feb 18;8(7):eabj7002. doi: 10.1126/sciadv.abj7002. Epub 2022 Feb 18. Sci Adv. 2022. PMID: 35179953 Free PMC article.
A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties.
Dooley K, McConnell RE, Xu K, Lewis ND, Haupt S, Youniss MR, Martin S, Sia CL, McCoy C, Moniz RJ, Burenkova O, Sanchez-Salazar J, Jang SC, Choi B, Harrison RA, Houde D, Burzyn D, Leng C, Kirwin K, Ross NL, Finn JD, Gaidukov L, Economides KD, Estes S, Thornton JE, Kulman JD, Sathyanarayanan S, Williams DE. Dooley K, et al. Among authors: jang sc. Mol Ther. 2021 May 5;29(5):1729-1743. doi: 10.1016/j.ymthe.2021.01.020. Epub 2021 Jan 21. Mol Ther. 2021. PMID: 33484965 Free PMC article.
Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12.
Lewis ND, Sia CL, Kirwin K, Haupt S, Mahimkar G, Zi T, Xu K, Dooley K, Jang SC, Choi B, Boutin A, Grube A, McCoy C, Sanchez-Salazar J, Doherty M, Gaidukov L, Estes S, Economides KD, Williams DE, Sathyanarayanan S. Lewis ND, et al. Among authors: jang sc. Mol Cancer Ther. 2021 Mar;20(3):523-534. doi: 10.1158/1535-7163.MCT-20-0484. Epub 2020 Dec 21. Mol Cancer Ther. 2021. PMID: 33443094
76 results