Knuckley B - Search Results

1

A peptoid-based inhibitor of protein arginine methyltransferase 1 (PRMT1) induces apoptosis and autophagy in cancer cells.

Brekker MA, Sartawi T, Sawatzky TM, Causey CP, Rehman FK, Knuckley B. Brekker MA, et al. Among authors: knuckley b. J Biol Chem. 2022 Aug;298(8):102205. doi: 10.1016/j.jbc.2022.102205. Epub 2022 Jun 25. J Biol Chem. 2022. PMID: 35764172 Free PMC article.

2

The development and characterization of a chemical probe targeting PRMT1 over PRMT5.

Mann SA, Salsburg A, Causey CP, Knuckley B. Mann SA, et al. Among authors: knuckley b. Bioorg Med Chem. 2019 Jan 1;27(1):224-229. doi: 10.1016/j.bmc.2018.12.001. Epub 2018 Dec 4. Bioorg Med Chem. 2019. PMID: 30529151

3

Histone H4-based peptoids are inhibitors of protein arginine methyltransferase 1 (PRMT1).

Mann SA, DeMart MK, May B, Causey CP, Knuckley B. Mann SA, et al. Among authors: knuckley b. Biochem J. 2020 Aug 28;477(16):2971-2980. doi: 10.1042/BCJ20200534. Biochem J. 2020. PMID: 32716034

4

Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases.

Thomson A, O'Connor S, Knuckley B, Causey CP. Thomson A, et al. Among authors: knuckley b. Bioorg Med Chem. 2014 Sep 1;22(17):4602-8. doi: 10.1016/j.bmc.2014.07.028. Epub 2014 Jul 25. Bioorg Med Chem. 2014. PMID: 25127464

5

Development of a clickable activity-based protein profiling (ABPP) probe for agmatine deiminases.

Marchenko M, Thomson A, Ellis TN, Knuckley B, Causey CP. Marchenko M, et al. Among authors: knuckley b. Bioorg Med Chem. 2015 May 1;23(9):2159-67. doi: 10.1016/j.bmc.2015.03.013. Epub 2015 Mar 9. Bioorg Med Chem. 2015. PMID: 25819331

6

Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential.

Jones JE, Causey CP, Knuckley B, Slack-Noyes JL, Thompson PR. Jones JE, et al. Among authors: knuckley b. Curr Opin Drug Discov Devel. 2009 Sep;12(5):616-27. Curr Opin Drug Discov Devel. 2009. PMID: 19736621 Free PMC article. Review.

7

The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.

Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR. Causey CP, et al. Among authors: knuckley b. J Med Chem. 2011 Oct 13;54(19):6919-35. doi: 10.1021/jm2008985. Epub 2011 Sep 16. J Med Chem. 2011. PMID: 21882827 Free PMC article.

8

Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.

Knuckley B, Causey CP, Jones JE, Bhatia M, Dreyton CJ, Osborne TC, Takahara H, Thompson PR. Knuckley B, et al. Biochemistry. 2010 Jun 15;49(23):4852-63. doi: 10.1021/bi100363t. Biochemistry. 2010. PMID: 20469888 Free PMC article.

9

A fluopol-ABPP HTS assay to identify PAD inhibitors.

Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR. Knuckley B, et al. Chem Commun (Camb). 2010 Oct 14;46(38):7175-7. doi: 10.1039/c0cc02634d. Epub 2010 Aug 25. Chem Commun (Camb). 2010. PMID: 20740228 Free PMC article.

10

Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation.

Knuckley B, Causey CP, Pellechia PJ, Cook PF, Thompson PR. Knuckley B, et al. Chembiochem. 2010 Jan 25;11(2):161-5. doi: 10.1002/cbic.200900698. Chembiochem. 2010. PMID: 20014086 Free PMC article.

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