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Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia.
Grüninger PK, Uhl F, Herzog H, Gentile G, Andrade-Martinez M, Schmidt T, Han K, Morgens DW, Bassik MC, Cleary ML, Gorka O, Zeiser R, Groß O, Duque-Afonso J. Grüninger PK, et al. Among authors: uhl f. Cancer Gene Ther. 2022 Nov;29(11):1751-1760. doi: 10.1038/s41417-022-00491-0. Epub 2022 Jul 6. Cancer Gene Ther. 2022. PMID: 35794338 Free PMC article.
The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior.
Weinberg F, Reischmann N, Fauth L, Taromi S, Mastroianni J, Köhler M, Halbach S, Becker AC, Deng N, Schmitz T, Uhl FM, Herbener N, Riedel B, Beier F, Swarbrick A, Lassmann S, Dengjel J, Zeiser R, Brummer T. Weinberg F, et al. Among authors: uhl fm. EBioMedicine. 2017 Jun;20:79-97. doi: 10.1016/j.ebiom.2017.04.015. Epub 2017 Apr 12. EBioMedicine. 2017. PMID: 28499923 Free PMC article.
Gab2 is Essential for Transformation by FLT3-ITD in Acute Myeloid Leukemia.
Sies K, Spohr C, Gründer A, Todorova R, Uhl FM, Huber J, Zeiser R, Pahl HL, Becker H, Aumann K, Brummer T, Halbach S. Sies K, et al. Hemasphere. 2019 Feb 22;3(2):e184. doi: 10.1097/HS9.0000000000000184. eCollection 2019 Apr. Hemasphere. 2019. PMID: 31723823 Free PMC article. No abstract available.
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation.
Hamarsheh S, Osswald L, Saller BS, Unger S, De Feo D, Vinnakota JM, Konantz M, Uhl FM, Becker H, Lübbert M, Shoumariyeh K, Schürch C, Andrieux G, Venhoff N, Schmitt-Graeff A, Duquesne S, Pfeifer D, Cooper MA, Lengerke C, Boerries M, Duyster J, Niemeyer CM, Erlacher M, Blazar BR, Becher B, Groß O, Brummer T, Zeiser R. Hamarsheh S, et al. Nat Commun. 2020 Apr 3;11(1):1659. doi: 10.1038/s41467-020-15497-1. Nat Commun. 2020. PMID: 32246016 Free PMC article.
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans.
Uhl FM, Chen S, O'Sullivan D, Edwards-Hicks J, Richter G, Haring E, Andrieux G, Halbach S, Apostolova P, Büscher J, Duquesne S, Melchinger W, Sauer B, Shoumariyeh K, Schmitt-Graeff A, Kreutz M, Lübbert M, Duyster J, Brummer T, Boerries M, Madl T, Blazar BR, Groß O, Pearce EL, Zeiser R. Uhl FM, et al. Sci Transl Med. 2020 Oct 28;12(567):eabb8969. doi: 10.1126/scitranslmed.abb8969. Sci Transl Med. 2020. PMID: 33115954 Free PMC article.
Fever supports CD8+ effector T cell responses by promoting mitochondrial translation.
O'Sullivan D, Stanczak MA, Villa M, Uhl FM, Corrado M, Klein Geltink RI, Sanin DE, Apostolova P, Rana N, Edwards-Hicks J, Grzes KM, Kabat AM, Kyle RL, Fabri M, Curtis JD, Buck MD, Patterson AE, Regina A, Field CS, Baixauli F, Puleston DJ, Pearce EJ, Zeiser R, Pearce EL. O'Sullivan D, et al. Among authors: uhl fm. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2023752118. doi: 10.1073/pnas.2023752118. Epub 2021 Jun 14. Proc Natl Acad Sci U S A. 2021. PMID: 34161266 Free PMC article.
Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease.
Haring E, Andrieux G, Uhl FM, Krausz M, Proietti M, Sauer B, Esser PR, Martin SF, Pfeifer D, Schmitt-Graeff A, Duyster J, Köhler N, Grimbacher B, Boerries M, Aumann K, Zeiser R, Apostolova P. Haring E, et al. Among authors: uhl fm. Haematologica. 2022 Jul 1;107(7):1538-1554. doi: 10.3324/haematol.2021.278387. Haematologica. 2022. PMID: 34407601 Free PMC article.
87 results