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Page 1
Synthetic Approaches to the New Drugs Approved During 2020.
Flick AC, Leverett CA, Ding HX, McInturff EL, Fink SJ, Mahapatra S, Carney DW, Lindsey EA, DeForest JC, France SP, Berritt S, Bigi-Botterill SV, Gibson TS, Watson RB, Liu Y, O'Donnell CJ. Flick AC, et al. Among authors: gibson ts. J Med Chem. 2022 Jul 28;65(14):9607-9661. doi: 10.1021/acs.jmedchem.2c00710. Epub 2022 Jul 14. J Med Chem. 2022. PMID: 35833579 Review.
Synthetic Approaches to the New Drugs Approved during 2019.
Flick AC, Leverett CA, Ding HX, McInturff E, Fink SJ, Mahapatra S, Carney DW, Lindsey EA, DeForest JC, France SP, Berritt S, Bigi-Botterill SV, Gibson TS, Liu Y, O'Donnell CJ. Flick AC, et al. Among authors: gibson ts. J Med Chem. 2021 Apr 8;64(7):3604-3657. doi: 10.1021/acs.jmedchem.1c00208. Epub 2021 Mar 30. J Med Chem. 2021. PMID: 33783211 Review.
Synthetic Approaches to the New Drugs Approved During 2021.
McInturff EL, France SP, Leverett CA, Flick AC, Lindsey EA, Berritt S, Carney DW, DeForest JC, Ding HX, Fink SJ, Gibson TS, Gray K, Hubbell AK, Johnson AM, Liu Y, Mahapatra S, McAlpine IJ, Watson RB, O'Donnell CJ. McInturff EL, et al. Among authors: gibson ts. J Med Chem. 2023 Aug 10;66(15):10150-10201. doi: 10.1021/acs.jmedchem.3c00501. Epub 2023 Aug 1. J Med Chem. 2023. PMID: 37528515 Review.
Synthetic Approaches to the New Drugs Approved During 2022.
France SP, Lindsey EA, McInturff EL, Berritt S, Carney DW, DeForest JC, Fink SJ, Flick AC, Gibson TS, Gray K, Johnson AM, Leverett CA, Liu Y, Mahapatra S, Watson RB. France SP, et al. Among authors: gibson ts. J Med Chem. 2024 Mar 28;67(6):4376-4418. doi: 10.1021/acs.jmedchem.3c02374. Epub 2024 Mar 15. J Med Chem. 2024. PMID: 38488755 Review.
Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1.
Sabat M, Carney DW, Hernandez-Torres G, Gibson TS, Balakrishna D, Zou H, Xu R, Chen CH, de Jong R, Dougan DR, Qin L, Bigi-Botterill SV, Chambers A, Miura J, Johnson LK, Ermolieff J, Johns D, Selimkhanov J, Kwok L, DeMent K, Proffitt C, Vu P, Lindsey EA, Ivetac T, Jennings A, Wang H, Manam P, Santos C, Fullenwider C, Manohar R, Flick AC. Sabat M, et al. Among authors: gibson ts. J Med Chem. 2024 Jun 27;67(12):10306-10320. doi: 10.1021/acs.jmedchem.4c00743. Epub 2024 Jun 13. J Med Chem. 2024. PMID: 38872300
De novo discovery of cyclic peptide inhibitors of IL-11 signaling.
Lear S, Tafi R, Di Biasio VA, Halkowycz P, Kamran R, Miura J, Gibson TS, Li J, Bleck B, Dall'Armi C, Demartis A, Henninot A. Lear S, et al. Among authors: gibson ts. Bioorg Med Chem. 2024 Nov 27;119:118017. doi: 10.1016/j.bmc.2024.118017. Online ahead of print. Bioorg Med Chem. 2024. PMID: 39756345 Free article.
Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase.
Dang Q, Liu Y, Cashion DK, Kasibhatla SR, Jiang T, Taplin F, Jacintho JD, Li H, Sun Z, Fan Y, DaRe J, Tian F, Li W, Gibson T, Lemus R, van Poelje PD, Potter SC, Erion MD. Dang Q, et al. J Med Chem. 2011 Jan 13;54(1):153-65. doi: 10.1021/jm101035x. Epub 2010 Dec 2. J Med Chem. 2011. PMID: 21126019
Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure.
Lanier M, Pickens J, Bigi SV, Bradshaw-Pierce EL, Chambers A, Cheruvallath ZS, Cole D, Dougan DR, Ermolieff J, Gibson T, Halkowycz P, Hirokawa A, Ivetac A, Miura J, Nunez E, Sabat M, Tyhonas J, Wang H, Wang X, Swann S. Lanier M, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):316-320. doi: 10.1021/acsmedchemlett.6b00481. eCollection 2017 Mar 9. ACS Med Chem Lett. 2017. PMID: 28337323 Free PMC article.
19 results