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Nonclinical safety evaluation of a novel ionizable lipid for mRNA delivery.
Toxicol Appl Pharmacol. 2022 Sep 15;451:116143. doi: 10.1016/j.taap.2022.116143. Epub 2022 Jul 16.
Toxicol Appl Pharmacol. 2022.
PMID: 35843341
Nonclinical safety evaluation of two vaccine candidates for herpes simplex virus type 2 to support combined administration in humans.
Piras F, Plitnick LM, Berglund P, Bernard MC, Desert P.
Piras F, et al. Among authors: desert p.
J Appl Toxicol. 2023 Apr;43(4):534-556. doi: 10.1002/jat.4404. Epub 2022 Nov 22.
J Appl Toxicol. 2023.
PMID: 36227735
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The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Murithi JM, Pascal C, Bath J, Boulenc X, Gnädig NF, Pasaje CFA, Rubiano K, Yeo T, Mok S, Klieber S, Desert P, Jiménez-Díaz MB, Marfurt J, Rouillier M, Cherkaoui-Rbati MH, Gobeau N, Wittlin S, Uhlemann AC, Price RN, Wirjanata G, Noviyanti R, Tumwebaze P, Cooper RA, Rosenthal PJ, Sanz LM, Gamo FJ, Joseph J, Singh S, Bashyam S, Augereau JM, Giraud E, Bozec T, Vermat T, Tuffal G, Guillon JM, Menegotto J, Sallé L, Louit G, Cabanis MJ, Nicolas MF, Doubovetzky M, Merino R, Bessila N, Angulo-Barturen I, Baud D, Bebrevska L, Escudié F, Niles JC, Blasco B, Campbell S, Courtemanche G, Fraisse L, Pellet A, Fidock DA, Leroy D.
Murithi JM, et al. Among authors: desert p.
Sci Transl Med. 2021 Jul 21;13(603):eabg6013. doi: 10.1126/scitranslmed.abg6013.
Sci Transl Med. 2021.
PMID: 34290058
Free PMC article.
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Nonclinical safety assessment of an mRNA Covid-19 vaccine candidate following repeated administrations and biodistribution.
Broudic K, Laurent S, Perkov V, Simon C, Garinot M, Truchot N, Latour J, Désert P.
Broudic K, et al. Among authors: desert p.
J Appl Toxicol. 2024 Mar;44(3):371-390. doi: 10.1002/jat.4548. Epub 2023 Sep 18.
J Appl Toxicol. 2024.
PMID: 37723625
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Exposure considerations in human safety assessment: Report from an EPAA Partners' Forum.
Cronin MTD, Ball N, Beken S, Bender H, Bercaru O, Caneva L, Corvaro M, Currie RA, Dawson JL, Desert P, Escher SE, Franco A, Irizar A, Mehta JM, Rogiers V, Tremblay RT, Westmoreland C, Maxwell G.
Cronin MTD, et al. Among authors: desert p.
Regul Toxicol Pharmacol. 2023 Oct;144:105483. doi: 10.1016/j.yrtph.2023.105483. Epub 2023 Aug 26.
Regul Toxicol Pharmacol. 2023.
PMID: 37640101
Free article.
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