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Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11.
Zhang L, Hobeika CS, Khabibullin D, Yu D, Filippakis H, Alchoueiry M, Tang Y, Lam HC, Tsvetkov P, Georgiou G, Lamb C, Stone E, Puigserver P, Priolo C, Henske EP. Zhang L, et al. Among authors: puigserver p. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2122840119. doi: 10.1073/pnas.2122840119. Epub 2022 Jul 8. Proc Natl Acad Sci U S A. 2022. PMID: 35867762 Free PMC article.
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation.
Mutlu B, Sharabi K, Sohn JH, Yuan B, Latorre-Muro P, Qin X, Yook JS, Lin H, Yu D, Camporez JPG, Kajimura S, Shulman GI, Hui S, Kamenecka TM, Griffin PR, Puigserver P. Mutlu B, et al. Among authors: puigserver p. Cell Chem Biol. 2024 Oct 17;31(10):1772-1786.e5. doi: 10.1016/j.chembiol.2024.09.001. Epub 2024 Sep 27. Cell Chem Biol. 2024. PMID: 39341205
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.
Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM. Mootha VK, et al. Among authors: puigserver p. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6570-5. doi: 10.1073/pnas.0401401101. Epub 2004 Apr 20. Proc Natl Acad Sci U S A. 2004. PMID: 15100410 Free PMC article.
The SLC25A47 locus controls gluconeogenesis and energy expenditure.
Yook JS, Taxin ZH, Yuan B, Oikawa S, Auger C, Mutlu B, Puigserver P, Hui S, Kajimura S. Yook JS, et al. Among authors: puigserver p. Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2216810120. doi: 10.1073/pnas.2216810120. Epub 2023 Feb 22. Proc Natl Acad Sci U S A. 2023. PMID: 36812201 Free PMC article.
136 results