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Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains.
Chen C, Saville JW, Marti MM, Schäfer A, Cheng MH, Mannar D, Zhu X, Berezuk AM, Banerjee A, Sobolewski MD, Kim A, Treat BR, Da Silva Castanha PM, Enick N, McCormick KD, Liu X, Adams C, Hines MG, Sun Z, Chen W, Jacobs JL, Barratt-Boyes SM, Mellors JW, Baric RS, Bahar I, Dimitrov DS, Subramaniam S, Martinez DR, Li W. Chen C, et al. Among authors: hines mg. iScience. 2022 Aug 19;25(8):104798. doi: 10.1016/j.isci.2022.104798. Epub 2022 Jul 20. iScience. 2022. PMID: 35875685 Free PMC article.
Human antibodies targeting ENPP1 as candidate therapeutics for cancers.
Chu X, Baek DS, Li W, Shyp T, Mooney B, Hines MG, Morin GB, Sorensen PH, Dimitrov DS. Chu X, et al. Among authors: hines mg. Front Immunol. 2023 Jan 25;14:1070492. doi: 10.3389/fimmu.2023.1070492. eCollection 2023. Front Immunol. 2023. PMID: 36761762 Free PMC article.
AI-based IsAb2.0 for antibody design.
Liang T, Sun ZY, Hines MG, Penrose KJ, Hao Y, Chu X, Mellors JW, Dimitrov DS, Xie XQ, Li W, Feng Z. Liang T, et al. Among authors: hines mg. Brief Bioinform. 2024 Jul 25;25(5):bbae445. doi: 10.1093/bib/bbae445. Brief Bioinform. 2024. PMID: 39285513 Free PMC article.
CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma.
Pascual-Pasto G, McIntyre B, Hines MG, Giudice AM, Garcia-Gerique L, Hoffmann J, Mishra P, Matlaga S, Lombardi S, Shraim R, Schürch PM, Yarmarkovich M, Hofmann TJ, Alikarami F, Martinez D, Tsang M, Gil-de-Gómez L, Spear TT, Bernt KM, Wolpaw AJ, Dimitrov DS, Li W, Bosse KR. Pascual-Pasto G, et al. Among authors: hines mg. Nat Commun. 2024 Aug 21;15(1):7141. doi: 10.1038/s41467-024-51337-2. Nat Commun. 2024. PMID: 39164224 Free PMC article.
Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains.
Chen C, Saville JW, Marti MM, Schäfer A, Cheng MH, Mannar D, Zhu X, Berezuk AM, Banerjee A, Sobolewski MD, Kim A, Treat BR, Da Silva Castanha PM, Enick N, McCormick KD, Liu X, Adams C, Hines MG, Sun Z, Chen W, Jacobs JL, Barratt-Boyes SM, Mellors JW, Baric RS, Bahar I, Dimitrov DS, Subramaniam S, Martinez DR, Li W. Chen C, et al. Among authors: hines mg. bioRxiv [Preprint]. 2022 Feb 24:2022.02.18.481058. doi: 10.1101/2022.02.18.481058. bioRxiv. 2022. Update in: iScience. 2022 Aug 19;25(8):104798. doi: 10.1016/j.isci.2022.104798 PMID: 35194603 Free PMC article. Updated. Preprint.