Chai J - Search Results

1

SLL-627 Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity.

Kong L, Shu X, Tang S, Ye R, Sun H, Jiang S, Li Z, Chai J, Fang Y, Lan Y, Yu L, Xie Q, Fu W, Wang Y, Li W, Qiu Z, Liu J, Shao L. Kong L, et al. Among authors: chai j. J Med Chem. 2022 Aug 11;65(15):10377-10392. doi: 10.1021/acs.jmedchem.2c00014. Epub 2022 Jul 28. J Med Chem. 2022. PMID: 35900351

2

Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with κ agonist and μ agonist/antagonist activity.

Sun JF, Wang YH, Chai JR, Li FY, Hang A, Lu G, Tao YM, Cheng Y, Chi ZQ, Neumeyer JL, Zhang A, Liu JG, Wang YJ. Sun JF, et al. Eur J Pharmacol. 2014 Oct 5;740:455-63. doi: 10.1016/j.ejphar.2014.06.045. Epub 2014 Jul 3. Eur J Pharmacol. 2014. PMID: 24998879

3

Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist.

Wang YH, Chai JR, Xu XJ, Ye RF, Zan GY, Liu GY, Long JD, Ma Y, Huang X, Xiao ZC, Dong H, Wang YJ. Wang YH, et al. Sci Rep. 2018 Sep 20;8(1):14087. doi: 10.1038/s41598-018-32568-y. Sci Rep. 2018. PMID: 30237513 Free PMC article.

4

Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation.

Deng YZ, Lu YC, Wu WW, Cheng L, Zan GY, Chai JR, Wang YJ, Chen Z, Liu JG. Deng YZ, et al. Neuropharmacology. 2020 May 15;168:108028. doi: 10.1016/j.neuropharm.2020.108028. Epub 2020 Mar 6. Neuropharmacology. 2020. PMID: 32151646

5

Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory.

Wang YJ, Yu C, Wu WW, Ju YY, Liu Y, Xu C, Long JD, Zan GY, Wei XY, Zhang LS, Chai JR, Chen Z, Liu JG. Wang YJ, et al. Mol Psychiatry. 2021 Nov;26(11):6218-6236. doi: 10.1038/s41380-021-01111-3. Epub 2021 May 7. Mol Psychiatry. 2021. PMID: 33963280

6

Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress.

Zan GY, Sun X, Wang YJ, Liu R, Wang CY, Du WJ, Guo LB, Chai JR, Li QL, Liu ZQ, Liu JG. Zan GY, et al. Acta Pharmacol Sin. 2022 Mar;43(3):577-587. doi: 10.1038/s41401-021-00677-6. Epub 2021 May 25. Acta Pharmacol Sin. 2022. PMID: 34035484 Free PMC article.

7

Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic.

Huang H, Li X, Xie P, Li X, Xu X, Qian Y, Yuan C, Meng X, Chai J, Chen J, Liu J, Wang W, Li W, Wang Y, Fu W, Liu J. Huang H, et al. Among authors: chai j. J Med Chem. 2021 Jul 8;64(13):9458-9483. doi: 10.1021/acs.jmedchem.1c00722. Epub 2021 Jun 21. J Med Chem. 2021. PMID: 34152138

8

Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile.

He Q, Wei Y, Liu X, Ye R, Kong L, Li Z, Jiang S, Yu L, Chai J, Xie Q, Fu W, Wang Y, Li W, Qiu Z, Liu J, Shao L. He Q, et al. Among authors: chai j. J Med Chem. 2021 Aug 26;64(16):12414-12433. doi: 10.1021/acs.jmedchem.1c01082. Epub 2021 Aug 13. J Med Chem. 2021. PMID: 34387468

9

Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion.

Wei YY, Ma Y, Yao SY, Kong LH, Liu X, Chai JR, Chen J, Li W, Wang YJ, Shao LM, Liu JG. Wei YY, et al. Among authors: chai jr. Acta Pharmacol Sin. 2022 Jun;43(6):1372-1382. doi: 10.1038/s41401-021-00761-x. Epub 2021 Sep 7. Acta Pharmacol Sin. 2022. PMID: 34493813 Free PMC article.

10

Amygdalar κ-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence.

Zan GY, Wang YJ, Li XP, Fang JF, Yao SY, Du JY, Wang Q, Sun X, Liu R, Shao XM, Long JD, Chai JR, Deng YZ, Chen YQ, Li QL, Fang JQ, Liu ZQ, Liu JG. Zan GY, et al. Cell Rep. 2021 Nov 2;37(5):109913. doi: 10.1016/j.celrep.2021.109913. Cell Rep. 2021. PMID: 34731618 Free article.

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